Carotid arterial hemodynamics in hypertension: acute administration of captopril or cadralazine

Cardiovascular Drugs and Therapy
P LacolleyM E Safar

Abstract

Arterial diameter, blood flow, and vascular resistance of the common carotid artery were studied together with the carotido-femoral pulse wave velocity in men with sustained essential hypertension before and after acute oral administration of either captopril or a hydralazinelike agent, cadralazine. The two drugs caused similar decreases in mean blood pressure and vascular resistance in the carotid area. While cadralazine did not change arterial diameter and pulse wave velocity, captopril caused a significant increase in arterial diameter and a decrease in pulse wave velocity. The study provided evidence that two drugs causing a similar reduction in blood pressure and dilatation of small arteries have different effects on the large common carotid artery. Only captopril caused an enhancement of arterial diameter and distensibility related to the pharmacologic action of the drug on the vascular wall.

References

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Citations

Jan 20, 2004·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·R Asmar
Apr 27, 2011·Hemodialysis International·Serena TorracaBiagio Di Iorio
Dec 26, 2001·Journal of the American Society of Nephrology : JASN·J L Tycho VuurmansHein A Koomans

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