Abstract
The aim of this study was to compare methods of quantifying calcification of the internal carotid artery. We examined 92 internal carotid artery endarterectomy specimens. Grey scale median (GSM) values were calculated from optimized B-mode scans. The degree of calcification was assessed using radiographic calcification grading. Plaques were processed histologically, and classified into: (1) calcium-rich hard plaques, (2) lipid-rich soft plaques, and (3) combined plaques. The specimens were scanned in CT-scanner. The calcium score was determined as described by Agatston. Histopathology and GSM results concurred in 39 out of 92 cases (kappa=0.088). There was no significant correlation between the calcium score and the median GSM value (R=0.005; P=0.959). Histology and CT morphology showed a significant concordance (P<0.001). Also CT and radiomorphological classification showed close agreement (R=0.628, P<0.001). Calcium scores calculated using CT morphology enable precise in vitro evaluation of the calcium content of plaques in the internal carotid. In contrast, grey scale median values do not adequately reflect calcification of plaques.
References
Aug 15, 1991·The New England Journal of Medicine·UNKNOWN North American Symptomatic Carotid Endarterectomy Trial CollaboratorsM Eliasziw
Mar 15, 1990·Journal of the American College of Cardiology·A S AgatstonR Detrano
Mar 1, 1995·Circulation·J A RumbergerR S Schwartz
Jan 13, 1998·Journal of the American College of Cardiology·G SangiorgiR S Schwartz
Jan 8, 1999·Stroke; a Journal of Cerebral Circulation·J A ArnoldT S Padayachee
Mar 4, 2000·Stroke; a Journal of Cerebral Circulation·P M RothwellC P Warlow
Mar 8, 2000·Acta Neurologica Scandinavica·G Schulte-AltedorneburgE B Ringelstein
Mar 23, 2000·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·L M PedroJ Fernandes e Fernandes
Apr 19, 2000·Zeitschrift für Kardiologie·T DenekeK M Müller
Jul 8, 2000·Stroke; a Journal of Cerebral Circulation·U SchminkeC Kessler
Feb 17, 2001·Ultrasound in Medicine & Biology·F RakebrandtJ P Woodcock
Jan 22, 2002·Journal of Vascular Surgery·Marie-Louise M GrønholdtHenrik Sillesen
Feb 2, 2002·Stroke; a Journal of Cerebral Circulation·Rozemarijn VliegenthartJacqueline C M Witteman
Feb 8, 2003·European Journal of Ultrasound : Official Journal of the European Federation of Societies for Ultrasound in Medicine and Biology·Christian DenzelWerner Lang
Jul 2, 2003·Radiology·Cheng HongFang Zhu
Jul 12, 2003·Stroke; a Journal of Cerebral Circulation·Christian DenzelWerner Lang
Citations
Mar 19, 2014·European Journal of Radiology·Shigeki YamadaHidenori Miyake
Jul 18, 2006·Journal of Computer Assisted Tomography·Toshiaki TaokaKimihiko Kichikawa
Oct 18, 2011·BMC Nephrology·Masaru NakayamaYoshiki Kaizu
Aug 27, 2015·International Journal of Molecular Sciences·Fisnik JashariMichael Y Henein
May 8, 2007·Atherosclerosis·Shyam PrabhakaranTatjana Rundek
Jun 25, 2009·Journal of Internal Medicine·S WangHung-Fat Tse
Sep 23, 2008·Journal of Vascular Surgery·Bas M Wallis de VriesClark J Zeebregts
Aug 8, 2015·Stroke; a Journal of Cerebral Circulation·Deepak SubediJoanna Wardlaw
May 28, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Catherine L HigginsJoel D Morrisett
Mar 19, 2005·Stroke; a Journal of Cerebral Circulation·J K LovettP M Rothwell
Sep 29, 2007·Stroke; a Journal of Cerebral Circulation·Hiroyuki Katano, Kazuo Yamada
Sep 17, 2009·The Journal of Rheumatology·Kai-Hang YiuHung-Fat Tse
Sep 2, 2010·Topics in Magnetic Resonance Imaging : TMRI·Niranjan BaluChun Yuan
Jul 4, 2018·Clinical Oral Investigations·Viveca Wallin BengtssonStefan Renvert
Feb 23, 2020·Biomarkers in Medicine·Shanshan HuangJianlei Zheng
Mar 20, 2019·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Jae Hoon LeeTae Kyung Koh
Feb 7, 2021·Diagnostics·Yamume TshombaRoberto Chiesa