Carotid artery calcium: accuracy of a calcium score by computed tomography-an in vitro study with comparison to sonography and histology

European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery
C DenzelW Lang

Abstract

The aim of this study was to compare methods of quantifying calcification of the internal carotid artery. We examined 92 internal carotid artery endarterectomy specimens. Grey scale median (GSM) values were calculated from optimized B-mode scans. The degree of calcification was assessed using radiographic calcification grading. Plaques were processed histologically, and classified into: (1) calcium-rich hard plaques, (2) lipid-rich soft plaques, and (3) combined plaques. The specimens were scanned in CT-scanner. The calcium score was determined as described by Agatston. Histopathology and GSM results concurred in 39 out of 92 cases (kappa=0.088). There was no significant correlation between the calcium score and the median GSM value (R=0.005; P=0.959). Histology and CT morphology showed a significant concordance (P<0.001). Also CT and radiomorphological classification showed close agreement (R=0.628, P<0.001). Calcium scores calculated using CT morphology enable precise in vitro evaluation of the calcium content of plaques in the internal carotid. In contrast, grey scale median values do not adequately reflect calcification of plaques.

References

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Citations

Mar 19, 2014·European Journal of Radiology·Shigeki YamadaHidenori Miyake
Aug 27, 2015·International Journal of Molecular Sciences·Fisnik JashariMichael Y Henein
May 8, 2007·Atherosclerosis·Shyam PrabhakaranTatjana Rundek
Sep 23, 2008·Journal of Vascular Surgery·Bas M Wallis de VriesClark J Zeebregts
May 28, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Catherine L HigginsJoel D Morrisett
Sep 29, 2007·Stroke; a Journal of Cerebral Circulation·Hiroyuki Katano, Kazuo Yamada
Sep 17, 2009·The Journal of Rheumatology·Kai-Hang YiuHung-Fat Tse
Sep 2, 2010·Topics in Magnetic Resonance Imaging : TMRI·Niranjan BaluChun Yuan
Feb 23, 2020·Biomarkers in Medicine·Shanshan HuangJianlei Zheng
Mar 20, 2019·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Jae Hoon LeeTae Kyung Koh

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