Carotid baroreflex control of leg vasculature in exercising and non-exercising skeletal muscle in humans

The Journal of Physiology
David M KellerPeter B Raven

Abstract

Carotid baroreflex (CBR) function was examined in five men and three women (25 +/- 1 years) using the variable-pressure neck collar technique at rest and during dynamic, one-legged knee extension exercise at 7 W and 25 W. The CBR exhibited control of leg vascular conductance (LVC) at rest and during exercise in both an exercising leg (EL) and a non-exercising leg (NEL) across a wide range of pressures from +40 Torr neck pressure (NP) to -80 Torr neck suction (NS). Specifically, increases in LVC (% change) in response to NS were no different across -20 to -80 Torr in either EL or NEL compared to rest, P > 0.05. However, CBR-mediated decreases in percentage LVC in response to NP were attenuated in EL at both 7 W (16 +/- 1%) and 25 W (12 +/- 1%) compared to rest (40 +/- 3%; P < 0.05) as well as compared to responses in the NEL (36 +/- 6% at 7 W and 36 +/- 7% at 25 W; P < 0.05). This decrease in vascular responsiveness in EL was associated with a reduction in the gain of the percentage muscle sympathetic nerve activity (%MSNA)-%LVC relationship compared to rest (P < 0.05). Collectively, these data indicate that, despite a clear attenuation of the vascular response to MSNA in the exercising leg, CBR-mediated changes in mean arterial...Continue Reading

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Citations

Mar 19, 2008·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Michael E Tschakovsky, Michael J Joyner
Mar 17, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Shigehiko OgohPaul J Fadel
Jul 13, 2013·European Journal of Applied Physiology·Masashi IchinoseTakeshi Nishiyasu
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Apr 12, 2008·The Journal of Physiology·Masashi IchinoseTakeshi Nishiyasu
Oct 8, 2005·Experimental Physiology·Peter B RavenShigehiko Ogoh
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Sep 19, 2012·Clinical Science·Zachary Barrett-O'KeefeD Walter Wray
Feb 9, 2018·Journal of Applied Physiology·Veronica J PoitrasMichael E Tschakovsky
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Dec 22, 2020·Experimental Physiology·Jaqueline Aparecida de SouzaLeonardo Máximo Cardoso

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