Carotid chemoreceptor modulation of sympathetic vasoconstrictor outflow during exercise in healthy humans.

The Journal of Physiology
Michael K SticklandJ A Dempsey

Abstract

Recently, we have shown that specific, transient carotid chemoreceptor (CC) inhibition in exercising dogs causes vasodilatation in limb muscle. The purpose of the present investigation was to determine if CC suppression reduces muscle sympathetic nerve activity (MSNA) in exercising humans. Healthy subjects (N = 7) breathed hyperoxic gas (F(IO(2)) approximately 1.0) for 60 s at rest and during rhythmic handgrip exercise (50% maximal voluntary contraction, 20 r.p.m.). Microneurography was used to record MSNA in the peroneal nerve. End-tidal P(CO(2)) was maintained at resting eupnoeic levels throughout and breathing rate was voluntarily fixed. Exercise increased heart rate (67 versus 77 beats min(-1)), mean blood pressure (81 versus 97 mmHg), MSNA burst frequency (28 versus 37 bursts min(-1)) and MSNA total minute activity (5.7 versus 9.3 units), but did not change blood lactate (0.7 versus 0.7 mm). Transient hyperoxia had no significant effect on MSNA at rest. In contrast, during exercise both MSNA burst frequency and total minute activity were significantly reduced with hyperoxia. MSNA burst frequency was reduced within 9-23 s of end-tidal P(O(2)) exceeding 250 mmHg. The average nadir in MSNA burst frequency and total minute act...Continue Reading

References

Oct 1, 1979·Physiological Reviews·A B VallboB G Wallin
Apr 1, 1976·Respiration Physiology·D AggarwalL Y Lee
Jul 1, 1975·Journal of Applied Physiology·J T MaherL I Rose
Oct 1, 1992·The American Journal of Physiology·M J JoynerD O Warner
Aug 1, 1992·Respiration Physiology·L C HensonB J Whipp
Dec 1, 1992·Journal of Applied Physiology·J M HillM P Kaufman
Sep 1, 1991·Journal of Applied Physiology·D R SealsR F Fregosi
May 1, 1991·The American Journal of Physiology·D R SealsR F Fregosi
Jan 1, 1990·Respiration; International Review of Thoracic Diseases·P SebertP Mialon
Aug 1, 1990·Journal of Applied Physiology·L B Rowell, D S O'Leary
Dec 1, 1986·Journal of Applied Physiology·C L Boetger, D S Ward
Feb 1, 1988·Journal of Applied Physiology·E B OlsonJ A Dempsey
Nov 1, 1987·The American Journal of Physiology·D D SheriffA M Scher
Dec 1, 1972·Journal of Applied Physiology·J V WeilG F Filley
Jun 1, 1973·Respiration Physiology·R O Davies, S Lahiri
Jun 1, 1974·Respiration Physiology·H V ForsterG Do Pico
Jul 1, 1981·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·S LahiriT Nishino
Jun 1, 1981·The Journal of Physiology·H Acker, R G O'Regan
Dec 1, 1981·Respiration Physiology·P C NyeR W Torrance
Feb 1, 1995·Journal of Applied Physiology·H BeckerC E Sullivan
Oct 1, 1994·Progress in Neurobiology·M K Sun, D J Reis
Jan 1, 1994·The American Journal of Physiology·M K Sun, D J Reis
Apr 1, 1993·Respiration Physiology·A BałkowiecP Szulczyk
Oct 1, 1996·Journal of Applied Physiology·H F BeckerC E Sullivan
Jul 17, 1999·The American Journal of Physiology·J B Buckwalter, P S Clifford
May 8, 2000·Journal of Applied Physiology·A K CurranC A Smith
Aug 30, 2000·Respiration Physiology·P G Guyenet
Dec 9, 2000·American Journal of Respiratory and Critical Care Medicine·P SolinM T Naughton
Oct 17, 2002·Respiratory Physiology & Neurobiology·Jerome A DempseyBarbara J Morgan
Oct 23, 2002·Journal of Applied Physiology·Hideaki NakayamaJerome A Dempsey
Mar 18, 2003·Journal of Hypertension·Henri J L M TimmersJacques W M Lenders
Dec 1, 1961·The Journal of Physiology·C EYZAGUIRRE, J LEWIN
Dec 1, 1961·The Journal of Physiology·C EYZAGUIRRE, J LEWIN
Jan 13, 2004·Journal of Applied Physiology·Jay B DeanRobert W Putnam
Sep 24, 2005·Journal of Applied Physiology·Ailiang XieJerome A Dempsey
Oct 8, 2005·Experimental Physiology·Peter B RavenShigehiko Ogoh
Jun 15, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Anne HoussièrePhilippe van de Borne

❮ Previous
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Citations

Nov 12, 2010·European Journal of Applied Physiology·Yoann GoleAlain Boussuges
Mar 13, 2012·European Journal of Applied Physiology·Stylianos N KounalakisIgor B Mekjavic
Mar 20, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Michael K SticklandJerome A Dempsey
Feb 13, 2010·Journal of Applied Physiology·Jordan S QueridoA William Sheel
Jul 19, 2008·Journal of Applied Physiology·Michael K Stickland, Jordan D Miller
May 13, 2014·BioMed Research International·Antonio C L NobregaAntonio Crisafulli
Jul 5, 2013·Current Hypertension Reports·Harold D SchultzRodrigo Del Rio
Jan 8, 2014·The Journal of Physiology·Piotr NiewinskiPiotr Ponikowski
Jun 19, 2012·The Journal of Physiology·Bruno M SilvaLauro C Vianna
Oct 26, 2011·The Journal of Physiology·Michael K SticklandM Sean McMurtry
Aug 9, 2008·The Journal of Physiology·Andrew T LoveringMarlowe W Eldridge
Jan 15, 2014·Experimental Physiology·Jacqueline K LimbergErica A Wehrwein
Jul 22, 2009·Respiratory Physiology & Neurobiology·C JanssenP van de Borne
Oct 21, 2015·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Catherine F NotariusJohn S Floras
Oct 6, 2009·Experimental Physiology·Christos K LykidisGeorge M Balanos
Aug 1, 2016·Sports Medicine·Billy SperlichJennifer Wegrzyk
Jun 30, 2016·PloS One·Michael K SticklandCraig D Steinback
Jan 11, 2011·European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology·Massimo F PiepoliUNKNOWN Working Group ‘Exercise Physiology, Sport Cardiology and Cardiac Rehabilitation’, Italian Society of Cardiology
Apr 14, 2018·Physiological Genomics·Jacqueline K Limberg
Nov 2, 2018·Journal of Applied Physiology·Jeremy D SeedPhilip J Millar
Jul 12, 2008·Journal of Applied Physiology·Roland D ThijsJohannes J van Lieshout
May 6, 2019·The Journal of Physiological Sciences : JPS·Keisho Katayama, Mitsuru Saito
May 20, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Keisho KatayamaMitsuru Saito
Sep 22, 2017·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Blair D JohnsonMichael J Joyner
Jan 24, 2015·Journal of Applied Physiology·Heather EdgellMichael K Stickland
Feb 28, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·H Edgell, M K Stickland
Sep 23, 2014·Journal of Applied Physiology·Sushant M RanadiveDarren P Casey
Oct 26, 2014·Physiological Reports·Matthew J Heffernan, Matthew D Muller
Sep 16, 2017·Journal of Applied Physiology·Joshua R SmithCarl J Ade
Apr 9, 2020·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Elizabeth P OttJacqueline K Limberg
Nov 21, 2019·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jacqueline K LimbergMichael J Joyner
Apr 1, 2020·Frontiers in Physiology·Sophie É CollinsMichael K Stickland
Apr 23, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Lindsay D DeBeckMichael K Stickland
Feb 12, 2021·Physiological Reviews·Rodrigo IturriagaVirend K Somers

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