Carotid Endarterectomy and Stenting in a Chinese Population: Safety Outcome of the Revascularization of Extracranial Carotid Artery Stenosis Trial.

Translational Stroke Research
Bin YangRECAS Trial Investigators

Abstract

Carotid endarterectomy (CEA) and carotid artery stenting (CAS) have been well-established as two effective treatment modalities for carotid artery stenosis, while their clinical outcomes in real-world China are still unknown due to lack of nationwide trials. We aimed to evaluate the safety outcome profile of CEA and CAS in Chinese patients with carotid artery stenosis. The Revascularization of Extracranial Carotid Artery Stenosis trial was a multicentre, prospective cohort study of CEA or CAS in treating patients with carotid artery stenosis. We included symptomatic or asymptomatic patients with carotid artery stenosis (≥ 50%). The primary endpoint was any stroke, myocardial infarction and/or death within 1 month post-procedure. Overall, 2719 cases (1543 CAS-treated patients and 1176 CEA-treated patients) were enrolled from 36 centres. The primary outcome was 4.3% (95% CI 3.2-5.6%) and 4.7% (95%CI 3.5-6.3%) in the symptomatic and asymptomatic patients, respectively. No significant difference in the primary outcome was found between CAS and CEA in both symptomatic (p = 0.338) and asymptomatic (p = 0.890) patients. High- versus low-volume centre significantly related to lower rate of primary outcome in CEA-treated patients (OR 2....Continue Reading

Associated Clinical Trials

References

Aug 15, 1991·The New England Journal of Medicine·UNKNOWN North American Symptomatic Carotid Endarterectomy Trial CollaboratorsM Eliasziw
Dec 3, 1999·Stroke; a Journal of Cerebral Circulation·G W PettyD O Wiebers
Aug 17, 2005·Journal of Vascular Surgery·UNKNOWN CaRESS Steering Committee
May 28, 2010·The New England Journal of Medicine·Thomas G BrottUNKNOWN CREST Investigators
Sep 22, 2010·International Journal of Stroke : Official Journal of the International Stroke Society·Xinfeng Liu, Gelin Xu
Dec 4, 2010·Stroke; a Journal of Cerebral Circulation·Larry B GoldsteinUNKNOWN Council on Peripheral Vascular Disease, and Interdisciplinary Council on Quality of Care and Outcomes Research
Apr 29, 2014·Journal of Neurology, Neurosurgery, and Psychiatry·Man Mohan MehndirattaMohammad Wasay
Apr 7, 2018·Journal of the American Heart Association·Xiaojun WangZuxun Lu

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Clinical Trials Mentioned

NCT01994187

Software Mentioned

RECAS
CARESS
SPSS
CREST

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