PMID: 18193707Jan 16, 2008Paper

Carotid endarterectomy in the UK: acceptable risks but unacceptable delays

Clinical Medicine : Journal of the Royal College of Physicians of London
D DellagrammaticasGALA trial collaborators

Abstract

Carotid endarterectomy (CEA) is of benefit for stroke prevention in the presence of severe carotid stenosis, provided surgical morbidity and mortality are acceptably low. To assess the current performance of CEA in the UK, an interim analysis of 30-day postoperative outcome data, blinded to anaesthetic allocation, from the first 1,001 UK patients randomised in the GALA Trial (multicentre randomised trial of general versus local anaesthesia for CEA) took place and the time from last symptomatic event to surgery was recorded. The 30-day risk of stroke was 5.3%, myocardial infarction (MI) 0.4%, death 1.7%, and stroke, MI or death 6.4%. Median delay between symptoms and surgery was 82 days. These risks are similar to those reported in the large randomised trials of CEA, but current delays to surgery are excessive and must have substantially reduced the benefit of endarterectomy.

Associated Clinical Trials

Jun 22, 2016·Natalie Domenick Sridharan

Citations

Feb 22, 2008·Der Anaesthesist·H W Gervais
Jun 9, 2009·BMJ : British Medical Journal·Alison W HallidayUNKNOWN Vascular Society of Great Britain and Ireland
Nov 23, 2013·The Surgeon : Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland·K A GabaZ Raza
Apr 23, 2013·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Erin DyerGary Ferguson
Jan 9, 2009·Annals of Vascular Surgery·J K RandallA S Brar
Dec 23, 2011·The British Journal of Surgery·N RudarakanchanaJ F Potter
May 20, 2014·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·G TsivgoulisS N Vasdekis
Apr 18, 2012·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·D PurkayasthaC N McCollum
Aug 30, 2008·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·O EhsanA da Silva
Mar 20, 2009·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·K Rerkasem, P M Rothwell
Sep 25, 2016·Journal of Vascular Surgery·Philippe CharbonneauStéphane Elkouri
Feb 24, 2009·Journal of Neurotrauma·G Burkhard MackensenDavid S Warner
Aug 28, 2010·Stroke; a Journal of Cerebral Circulation·Waleed BrinjikjiGiuseppe Lanzino
Apr 20, 2013·Stroke; a Journal of Cerebral Circulation·Wesley P StuartGeorge H Welch
Oct 20, 2012·Journal of Cardiovascular Medicine·Luciano CandilioDerek J Hausenloy

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