Carotid Intima-Media Thickness and Markers of Brain Health in a Biracial Middle-Aged Cohort: CARDIA Brain MRI Sub-study

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Pavla CermakovaLenore J Launer

Abstract

We investigated whether carotid intima-media thickness is associated with measures of cerebral blood flow (CBF), white matter hyperintensities, and brain volume in a biracial cohort of middle-aged individuals. We performed a cross-sectional cohort study based on data from a multicenter, population-based study Coronary Artery Risk Development in Young Adults. Using linear and logistic regression, we estimated the association of the composite intima-media thickness measured in three segments of carotid arteries (common carotid artery, carotid artery bulb, and internal carotid artery) with volume (cm3) and CBF (mL/100 g/min) in the total brain and gray matter as well as volume of white matter hyperintensities (cm3). In the analysis, 461 participants (54% women, 34% African Americans) were included. Greater intima-media thickness was associated with lower CBF in gray matter (β=-1.36; p = .04) and total brain (β=-1.26; p = .04), adjusting for age, sex, race, education, and total brain volume. The associations became statistically nonsignificant after further controlling for cardiovascular risk factors. Intima-media thickness was not associated with volumes of total brain, gray matter, and white matter hyperintensities. This study su...Continue Reading

References

Jan 1, 1988·Journal of Clinical Epidemiology·G D FriedmanP J Savage
Sep 27, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Alex E RoherThomas G Beach
Jun 2, 2005·Annals of Neurology·Annemieke RuitenbergMonique M B Breteler
Mar 1, 2007·Annals of Neurology·Marieke van OijenMonique M B Breteler
Jul 12, 2007·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Meike W VernooijMonique M B Breteler
Mar 7, 2009·Stroke; a Journal of Cerebral Circulation·José R RomeroPhilip A Wolf
Jan 2, 2010·Stroke; a Journal of Cerebral Circulation·Jitka SojkovaSusan M Resnick
Jun 21, 2011·American Journal of Epidemiology·Catherine KimAnjel M Vahratian
Mar 1, 2012·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Joel AanerudAlbert Gjedde
Jul 31, 2012·Journal of Alzheimer's Disease : JAD·Jack C de la Torre
Dec 18, 2012·Cardiovascular Psychiatry and Neurology·Jack C de la Torre
Apr 2, 2014·Circulation·Kristine YaffeStephen Sidney
May 23, 2014·Current Vascular Pharmacology·Anne M DorrancePaulo W Pires
Mar 5, 2015·Stroke; a Journal of Cerebral Circulation·Jae Hoon MoonHak Chul Jang
Mar 12, 2016·Stroke; a Journal of Cerebral Circulation·Pauline MaillardCharles DeCarli
Aug 12, 2016·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Bjørn Heine StrandEspen Bjertness
Sep 19, 2016·Journal of the American Medical Directors Association·Pavla CermakovaDorota Religa
Dec 16, 2016·Hypertension·Costantino IadecolaUNKNOWN American Heart Association Council on Hypertension; Council on Clinical Cardiology; Council on Cardiovascular Disease in the
May 28, 2017·Journal of Alzheimer's Disease : JAD·Pavla CermakovaDorota Religa
Jun 8, 2017·Circulation·Frank J WoltersUNKNOWN Heart-Brain Connection Collaborative Research Group
Jul 8, 2017·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Nanna ArngrimMessoud Ashina
Apr 15, 2018·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Clifford R JackUNKNOWN Contributors
Sep 28, 2018·Neurology·Pavla CermakovaPetr Winkler
Oct 13, 2018·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Kevin J SullivanMary Ganguli
Feb 12, 2019·Translational Psychiatry·Martine ElbejjaniLenore J Launer

❮ Previous
Next ❯

Citations

Oct 15, 2019·Journal of Alzheimer's Disease : JAD·Dominika SeblovaPavla Cermakova
Mar 16, 2019·European Psychiatry : the Journal of the Association of European Psychiatrists·Tomas FormanekPavla Cermakova
Nov 5, 2019·Frontiers in Aging Neuroscience·Kathleen B MillerJill N Barnes
Oct 23, 2020·Preventive Medicine Reports·Paul KnektArpo Aromaa
Nov 21, 2021·Current Opinion in Lipidology·Sahil KhannaLisa B VanWagner

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Biomarkers for Cardiovascular Risk Assessment

Sensitive and accurate biomarkers used in cardiovascular risk prediction can potentially be used to manage the risk of cardiovascular disease. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here.