Carotid intima-media thickness and plaque volume changes following 2-year angiotensin II-receptor blockade. The Multicentre Olmesartan atherosclerosis Regression Evaluation (MORE) study

Therapeutic Advances in Cardiovascular Disease
Klaus O StumpeMORE study investigators

Abstract

The Multicentre Olmesartan atherosclerosis Regression Evaluation (MORE) study was a double-blind trial in patients with hypertension at increased cardiovascular risk with carotid wall thickening and a defined atherosclerotic plaque that used non-invasive 2- and 3-dimensionaL (D) ultrasound (US), to compare the effects of a 2-year treatment based on either olmesartan medoxomil or atenolol on common carotid (CC) intima-media thickness (IMT) and plaque volume (PV). A total of 165 patients (with systolic/diastolic blood pressure 140-180/ 90-105 mmHg) were randomized to receive either olmesartan (20-40 mg/day) or atenolol (50-100 mg/day). US was performed at baseline and 28, 52 and 104 weeks. The primary efficacy outcome was the change from baseline ( Delta) in CC-IMT assessed by 2D US. Secondary outcomes included Delta PV assessed by 3D US and blood pressure (BP). Olmesartan and atenolo produced comparable significant reductions in CC-IMT; mean Delta IMT (SEM) was -0.090 (0.015) mm for oLmesartan and -0.082 (0.014) mm for atenolol. Mean Delta PV was -4.4 (2.3) microl and 0.1 (1.5) microl in the olmesartan and atenolol treated subjects, respectively, without significant between-treatment differences. In the subgroup of patients with...Continue Reading

References

Feb 1, 1994·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·J PerssonG Berglund
Jun 1, 2001·Physics in Medicine and Biology·A FensterH N Cardinal
Apr 23, 2002·Journal of Human Hypertension·M Miyazaki, S Takai
Mar 16, 2004·Stroke; a Journal of Cerebral Circulation·Anthony LandryAaron Fenster
Nov 9, 2004·Lancet·Bo CarlbergLars Hjalmar Lindholm
Jun 10, 2006·Stroke; a Journal of Cerebral Circulation·Ji-Guang WangMichel Safar

❮ Previous
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Citations

Jul 10, 2009·Cardiovascular Research·Eric Thorin, Nathalie Thorin-Trescases
Oct 5, 2010·Circulation Research·Daniel BatlleMirza S Khan
Jun 15, 2012·Cardiovascular Diabetology·Yao-Chen ChuangKwang-Ming Fang
Aug 30, 2008·Cardiovascular Ultrasound·Malte LudwigKlaus O Stumpe
Jan 1, 2010·Integrated Blood Pressure Control·Eduardo Pimenta, Suzanne Oparil
May 14, 2009·Vascular Health and Risk Management·Carlos Ferrario
Jul 1, 2008·Future Cardiology·Christoph Schindler, Carlos M Ferrario
Jan 18, 2014·High Blood Pressure & Cardiovascular Prevention : the Official Journal of the Italian Society of Hypertension·Stefano OmboniMassimo Volpe
Jan 6, 2011·Current Atherosclerosis Reports·Alberto Ranieri De Caterina, Antonio Maria Leone
Jul 31, 2010·Cardiology Research and Practice·Mohamad C N Sinno, Mouaz Al-Mallah
May 21, 2011·AJNR. American Journal of Neuroradiology·A ChienF Viñuela
Nov 1, 2012·Der Internist·F Masuhr, M A Busch
Sep 1, 2008·Expert Review of Clinical Pharmacology·Mark Greathouse
Apr 9, 2013·Expert Opinion on Drug Metabolism & Toxicology·Carlos Escobar, Vivencio Barrios
Aug 20, 2009·Expert Opinion on Drug Metabolism & Toxicology·Maurizio DestroFrancesca Cagnoni
Feb 25, 2009·Expert Opinion on Pharmacotherapy·Silvia BarraGiovanni Gaeta
Jun 22, 2012·The Canadian Journal of Cardiology·Omar de RitaJ David Spence
Jan 31, 2012·Annals of Vascular Surgery·Christopher A DurhamMichael C Stoner
Jan 24, 2012·International Journal of Stroke : Official Journal of the International Stroke Society·Francisco PurroyGerard Piñol-Ripoll
Jun 30, 2010·Fundamental & Clinical Pharmacology·Anne-Isabelle TropeanoPatrick Maison
Apr 29, 2015·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Xin GongYong Zou
Jun 15, 2011·Atherosclerosis·Gregory C MakrisAndrew N Nicolaides
Nov 21, 2014·Cardiovascular Drugs and Therapy·Dimitris TousoulisChristodoulos Stefanadis
Jun 3, 2017·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Carlos M Ferrario, Adam E Mullick
Jan 10, 2012·Therapeutic Advances in Cardiovascular Disease·Serap Erdine
Nov 22, 2015·Journal of the American Heart Association·Wolfgang LiebRamachandran S Vasan
May 18, 2013·Hospital Practice·Christopher T Johnson, Luke P Brewster
Feb 15, 2013·Journal of Hypertension·Alejandro de la Sierra, Massimo Volpe
Oct 1, 2008·High Blood Pressure & Cardiovascular Prevention : the Official Journal of the Italian Society of Hypertension·Enrico Agabiti Rosei
Sep 29, 2012·American Journal of Therapeutics·Manuel VelascoValmore B Pirela
Feb 14, 2018·Cardiovascular Endocrinology & Metabolism·Gerardo Rodriguez-Araujo, Hironori Nakagami

❮ Previous
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