Carotid intima-media thickness and cerebrovascular disease in community-dwelling older people without stroke.

Stroke; a Journal of Cerebral Circulation
Susan D ShenkinJoanna M Wardlaw

Abstract

Carotid intima-media thickness (CIMT) is a noninvasive measure of atherosclerosis, but it is unclear whether it is a stronger risk factor for large vessel disease or small vessel disease. One hundred seven volunteers, aged 75 to 81 years, underwent measurements of CIMT and vascular risk factors and brain MRI (structural and diffusion tensor); those with history of stroke were excluded. In 96 subjects without stroke, there were significant associations between CIMT and markers of large vessel disease (carotid stenosis: rho=0.28; P=0.01) and intermediary risk factors (systolic blood pressure: rho=0.34; P=0.001). However, there were no significant associations between CIMT and markers of small vessel disease (white matter lesion load and water diffusion parameters). CIMT was not associated with neuroimaging biomarkers of small vessel disease in older volunteers without stroke. Any association between CIMT and white matter lesion in previous studies is likely to be mediated via common intermediary risk factors like hypertension.

References

Aug 1, 1987·AJR. American Journal of Roentgenology·F FazekasR A Zimmerman
Aug 21, 2002·Cerebrovascular Diseases·Fernando PicoAnnick Alpérovitch
Mar 18, 2004·Cerebrovascular Diseases·Konstantinos N VemmosMyron Mavrikakis
Apr 3, 2004·Stroke; a Journal of Cerebral Circulation·Frank-Erik de LeeuwMonique M B Breteler
May 27, 2006·Stroke; a Journal of Cerebral Circulation·Georgios TsivgoulisNikolaos Zakopoulos
Feb 27, 2007·Stroke; a Journal of Cerebral Circulation·D Martijn O PruissenUNKNOWN SMART Study Group
Mar 7, 2009·Stroke; a Journal of Cerebral Circulation·José R RomeroPhilip A Wolf

❮ Previous
Next ❯

Citations

Oct 12, 2012·Cardiovascular Psychiatry and Neurology·Ioannis HeliopoulosGeorgios Tsivgoulis
Aug 13, 2011·Journal of Aging Research·Cristina SierraAntonio Coca
Nov 25, 2011·International Journal of Stroke : Official Journal of the International Stroke Society·Joanna M WardlawIan J Deary
Oct 25, 2016·Current Opinion in Behavioral Sciences·Keren BachiNelly Alia-Klein
Aug 25, 2019·Behavioral Sciences·Zenaida Milagros Hernández-DíazAnay Cordero-Eiriz

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carotid Artery Diseases

Carotid artery disease is a group of pathological conditions of the carotid artery. Discover the latest research on carotid artery disease here.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.

Related Papers

Revista Portuguesa De Cardiologia : Orgão Oficial Da Sociedade Portuguesa De Cardiologia = Portuguese Journal of Cardiology : an Official Journal of the Portuguese Society of Cardiology
Ana Teresa TimóteoRui Cruz Ferreira
Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography
Michael LucKirk Spencer
© 2021 Meta ULC. All rights reserved