Carotid intima media thickness, brachial flow mediated dilation and previous history of gestational diabetes mellitus

The Journal of Obstetrics and Gynaecology Research
Hossein FakhrzadehBagher Larijani

Abstract

Gestational diabetes mellitus (GDM) is a common pregnancy condition with long-term complications. We examined the association between inflammatory mediators and early atherosclerosis process by measuring the flow mediated dilatation (FMD) of brachial artery and carotid intima media thickness (CIMT) in women with previous GDM (pGDM). Women with and without pGDM with an average of 4 years following the indexed pregnancy, participated in this study. Serum levels of IL-6, hs-CRP, adiponectin, homocystein and other biomedical parameters were measured. The existence of early atherogenesis process was evaluated by measuring CIMT and FMD. HOMA-IR and insulin were significantly higher in women with pGDM. Women with pGDM had slightly higher CIMT and significantly lower percent of brachial FMD. FMD and CIMT, adjusted for age and blood pressure, showed the same pattern. FMD showed no correlation with biochemical or inflammatory markers. Follow-up of this group of women, who are at increased risk of cardiovascular disease, with FMD should be considered.

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Citations

Aug 21, 2013·European Journal of Endocrinology·H IjäsM Vääräsmäki
Jan 31, 2014·Journal of Diabetes and Metabolic Disorders·Sudabeh AlatabYaser Tagalizadehkhoob
Apr 17, 2014·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Alina SokupMałgorzata Walentowicz-Sadłecka
Mar 22, 2014·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Omer GungorGulengul Koken
Apr 4, 2015·Heart Views : the Official Journal of the Gulf Heart Association·Ritu KaroliFaraz Ahmad Khan
Nov 13, 2015·Journal of Diabetes and Metabolic Disorders·Ozra Tabatabaei-MalazyBagher Larijani
Dec 14, 2016·International Journal of Endocrinology·S BurlinaA Lapolla
Mar 5, 2016·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Louise A JensenEdmond A Ryan
Oct 28, 2020·Reviews in Endocrine & Metabolic Disorders·Maleesa M PathiranaPrabha H Andraweera
Mar 30, 2021·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·S BurlinaA Lapolla

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