Carotid Intima-Media Thickness but Not Carotid Artery Plaque in Healthy Individuals Is Linked to Lean Body Mass

Journal of the American Heart Association
Matthew ArnoldChina Kadoorie Biobank Collaborative Group

Abstract

Background Lean body mass has been identified as a key determinant of left ventricular mass and wall thickness. However, the importance of lean body mass or other body-size measures as normative determinants of carotid intima-media thickness (cIMT), a widely used early indicator of atherosclerosis, has not been well established. Methods and Results Carotid artery ultrasound measurements of cIMT and carotid artery plaque burden (derived from plaque number and maximum size) and measurements of body size, including height, body mass index, weight, body fat proportion, and lean body mass ([1-body fat proportion]×weight), were recorded in 25 020 participants from 10 regions of China. Analyses were restricted to a healthy younger subset (n=6617) defined as never or long-term ex-regular smokers aged <60 years (mean age, 50) without previous ischemic heart disease, stroke, diabetes mellitus, or hypertension and with plasma non-high-density lipoprotein cholesterol <4 mmol/L. Among these 6617 participants, 86% were women (because most men smoked) and 9% had carotid artery plaque. In both women and men separately, lean body mass was strongly positively associated with cIMT, but was not associated with plaque burden: overall, each 10 kg hi...Continue Reading

References

Aug 26, 1998·Journal of the American College of Cardiology·H W HenseH Schunkert
Oct 6, 2007·Preventive Cardiology·Wendy S TzouJames H Stein
Nov 7, 2007·Annals of Epidemiology·Jina ChooChol Shin
Sep 12, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Mieczysław Litwin, Anna Niemirska
Dec 1, 2009·American Journal of Human Genetics·Jieming ChenJianjun Liu
Dec 14, 2011·International Journal of Epidemiology·Zhengming ChenUNKNOWN China Kadoorie Biobank (CKB) collaborative group
Jan 17, 2012·Diabetes & Metabolism Journal·Eun Sung KimJustin Y Jeon
May 10, 2012·Stroke; a Journal of Cerebral Circulation·Peter H WhincupJohn E Deanfield
Sep 15, 2012·Clinical Journal of the American Society of Nephrology : CJASN·Tammy M BradyMark Mitsnefes
Nov 29, 2012·European Heart Journal·Lian EngelenUNKNOWN Reference Values for Arterial Measurements Collaboration
Sep 10, 2013·Circulation. Cardiovascular Imaging·Stefan PfaffenbergerJulia Mascherbauer
Feb 12, 2014·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Shahryar M ChowdhuryTom Hulsey
Feb 7, 2016·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Bethany J FosterMark Mitsnefes
Oct 28, 2016·Nature Neuroscience·Karla L MillerStephen M Smith
Dec 22, 2016·Journal of the American Heart Association·Guang HaoGaston Kapuku
Jan 28, 2017·European Journal of Preventive Cardiology·Robert ClarkeUNKNOWN China Kadoorie Biobank Collaborative Group
Feb 27, 2017·Stroke; a Journal of Cerebral Circulation·Carrington R WendellAlan B Zonderman
May 20, 2017·Journal of the American College of Cardiology·Morten Fenger-GrønLars Frost
Sep 14, 2018·Pediatric Cardiology·Hubert KrysztofiakŁukasz A Małek
Oct 26, 2018·BMC Medicine·Florence Y LaiNilesh J Samani
Feb 6, 2019·European Heart Journal·Emmi TikkanenErik Ingelsson
Jun 1, 2019·JAMA Network Open·Sarah ParishUNKNOWN China Kadoorie Biobank Collaborative Group

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