Carotid intima-media thickness, but not chronic kidney disease independently associates with noncardiac arterial vascular events in South Africa

Journal of Hypertension
Andrea Kolkenbeck-RuhGavin R Norton

Abstract

Although chronic kidney disease (CKD) as determined from estimated glomerular filtration rate (eGFR) is recommended for risk prediction by current hypertension guidelines, the equations to derive eGFR may not perform well in black Africans. We compared whether across the adult lifespan, eGFR or CKD are as closely associated with noncardiac arterial vascular events, as carotid intima-media thickness (IMT), in Africa. In 1152 black South Africans [480 with noncardiac arterial events (294 with critical lower limb ischemia, 186 with stroke) of which 37% were premature] and 672 age, sex and ethnicity-matched controls from a randomly selected community sample, we assessed relations between eGFR, CKD or carotid IMT (B-mode ultrasound) and arterial events. From 20 years until old age, with or without adjustments, IMT was increased in those with as compared with without events (P < 0.01 at each decade of age). However, at any decade of age across the adult lifespan neither creatinine concentrations, nor eGFR were altered in those with arterial events (P > 0.28). Although IMT was strongly and independently associated with the odds of an event [odds ratio per 1 SD (0.171 mm) effect = 2.19, confidence interval = 1.75-2.78, P < 0.0001], nei...Continue Reading

References

Aug 19, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·J P ColletG Montalescot
Feb 9, 2007·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Walter Stefan SpeidlKurt Huber
Apr 28, 2007·International Journal of Cardiology·Javier PinedaFrancisco Sogorb
May 6, 2009·Annals of Internal Medicine·Andrew S LeveyUNKNOWN CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration)
Jan 27, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·John B EastwoodFrancesco P Cappuccio
Mar 2, 2010·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Kunihiro MatsushitaJosef Coresh
Mar 20, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Wieneke Marleen MichelsRaymond Theodorus Krediet
Oct 22, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Hendrick E van DeventerJaya A George
May 9, 2012·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Kunihiro MatsushitaUNKNOWN Alberta Kidney Disease Network
Oct 9, 2013·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Xianwei WangUNKNOWN China National Stroke Registry Investigators
Mar 29, 2014·Current Opinion in Nephrology and Hypertension·Edmund J Lamb, Paul E Stevens
Mar 30, 2016·Current Opinion in Nephrology and Hypertension·Maneesh Sud, David M J Naimark
Apr 13, 2017·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Alexander MilgromCharles J Glueck
May 4, 2017·Clinical and Experimental Pharmacology & Physiology·Yosuke HirakawaReiko Inagi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.