Carotid intima media thickness decreases after pancreas transplantation

Transplantation
Jennifer L LarsenJohn Leone

Abstract

Pancreas transplantation (PTX) improves diabetic microvascular complications, but it is unknown whether PTX alters macrovascular disease. Carotid intima media thickness (IMT) has been shown to correlate with cardiovascular events, so this study was designed to evaluate changes in carotid IMT after PTX. Four groups were studied: PTX candidates (n=60); successful PTX recipients (n=89; mean time since PTX=4.0+/-0.3 years); patients with type 1 diabetes but without nephropathy (n=20); and normal controls (n=32). Mean IMT and mean of maximum carotid IMT measurements (mean-max IMT), hemoglobin A1C, serum creatinine, body mass index (BMI), blood pressure, smoking status, use of hypolipidemic medications, and fasting lipids were determined in all groups. Age, gender distribution, and BMI were not different among the groups. Duration of diabetes was also equal between pre- and post-PTX groups. Mean and mean-max IMT were greatest pre-PTX and decreased after PTX (P<0.05) to a value that was not different from controls. Hemoglobin A1C and creatinine decreased, and high density lipoprotein (HDL) increased after PTX (P<0.05), but there were no significant differences in other lipids, BMI, use of lipid lowering agents, blood pressure, or smok...Continue Reading

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Citations

Mar 20, 2003·Current Diabetes Reports·Jennifer LarsenLynn Mack-Shipman
Sep 11, 2010·Current Diabetes Reports·Barbara LudwigStefan R Bornstein
Feb 13, 2004·The New England Journal of Medicine·R Paul Robertson
Feb 9, 2011·Diabetes Technology & Therapeutics·Cyrus JahansouzKenneth L Brayman
Dec 23, 2004·Transplantation·John MendeloffMary Amanda Dew
Jul 26, 2012·Current Diabetes Reports·Ugo BoggiGabriella Amorese
Jul 29, 2008·Current Opinion in Organ Transplantation·Patrick G DeanMark D Stegall
Dec 17, 2009·Current Opinion in Organ Transplantation·Chiara GremizziAntonio Secchi
Jan 4, 2013·Current Opinion in Organ Transplantation·Ugo BoggiPiero Marchetti
Feb 19, 2009·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·P Schenker, R Viebahn
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Jul 10, 2007·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·R Todd HurstBijoy Khandheria
Jul 6, 2004·Clinical Transplantation·Gunnela NordénGudrun Nyberg
Aug 17, 2005·Transplant International : Official Journal of the European Society for Organ Transplantation·G BiesenbachR Margreiter
Jun 29, 2004·Diabetes Care·Jennifer L LarsenLynn R Mack-Shipman
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Apr 16, 2003·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·K Sudhakar ReddyDinesh Ranjan

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