Apr 21, 2007

Carotid intima-media thickness in HIV patients treated with antiretroviral therapy

Clinical Physiology and Functional Imaging
Anne-Mette LebechAndreas Kjaer

Abstract

Increased cardiovascular risk in HIV patients in antiretroviral therapy (ART) may be due to HIV infection, direct effect of ART or dyslipidaemia induced by ART. Our aim was to study the relative importance of HIV, ART and dyslipidaemia on atherosclerosis, assessed by the comparison of carotid artery intima-media thickness (IMT) in non-smoking HIV patients with high or low serum cholesterol levels as well as in healthy volunteers. HIV patients in ART with normal cholesterol (<or=5 x 5 mmol l(-1); n=13) or high cholesterol (>or=6 x 5 mmol l(-1); n=12) as well as healthy controls (n=14) were included. All were non-smokers and had never received medication for dyslipidaemia or hypertension. IMT was measured by ultrasonography. In HIV patients with normal cholesterol (<or=5 x 5 mmol l(-1)), in HIV patients with hypercholesterolaemia (>or=6 x 5 mmol l(-1)) and in controls (5 x 1 +/- 0 x 9 mmol l(-1)) IMT were 683 +/- 119, 656 +/- 99 and 657 +/- 99 microm, respectively. Thus no difference in IMT was found between the three groups. IMT values did not differ between patients receiving and not receiving protease inhibitors (658 +/- 117 microm versus 687 +/- 97 microm, P>0 x 05). In HIV patients IMT correlated inversely with HDL cholester...Continue Reading

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References

Mentioned in this Paper

Intima
Protease Inhibitors [MoA]
Tunica Intima
Low Density Lipoprotein Cholesterol Measurement
Common Carotid Artery
Entire Carotid Artery
Total cholesterol
Serum HDL Cholesterol Measurement
HIV Infections
Hypercholesterolemia

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