Carotid Intima-media Thickness Measurements: Relations with Atherosclerosis, Risk of Cardiovascular Disease and Application in Randomized Controlled Trials

Chinese Medical Journal
M L BotsRudy Meijer

Abstract

Advances in the field of carotid ultrasound have been incremental, resulting in a steady decrease in measurement variability. Improvements in edge detection algorithms point toward increasing automation of CIMT measurements. The major advantage of CIMT is that it is completely noninvasive and can be repeated as often as required. It provides a continuous measure since all subjects have a measurable carotid wall. It is also relatively inexpensive to perform, and the technology is widely available. A graded relation between raising LDL cholesterol and increased CIMT is apparent. Increased CIMT has been shown consistently to relate the atherosclerotic abnormalities elsewhere in the arterial system. Moreover, increased CIMT predicts future vascular events in both populations from Caucasian ancestry and those from Asian ancestry. Furthermore, lipid‑lowering therapy has been shown to affect CIMT progression within 12–18 months in properly designed trials with results congruent with clinical events trials. In conclusion, when one wants to evaluate the effect of a pharmaceutical intervention that is to be expected to beneficially affect atherosclerosis progression and to reduce CV event risk, the use of CIMT measurements over time is a...Continue Reading

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Citations

Jan 18, 2018·Chinese Medical Journal·Dan-Yang Tian, Dong-Sheng Fan
Aug 16, 2019·Arteriosclerosis, Thrombosis, and Vascular Biology·José M ValdivielsoAlberto Ortiz
Oct 17, 2019·Metabolic Syndrome and Related Disorders·Rajesh Parsanathan, Sushil K Jain
Feb 6, 2018·Clinical and Experimental Hypertension : CHE·Seijiro ShimadaJunkichi Hama
Nov 26, 2016·Biogerontology·James J AndersonDavid J Sharrow
Mar 1, 2020·European Journal of Clinical Investigation·Lena TschidererPeter Willeit
Jul 16, 2019·Journal of the American Heart Association·Engelbert A NonterahUNKNOWN as members and collaborators of AWI‐Gen and the H3Africa Consortium
Apr 24, 2020·Frontiers in Pharmacology·Tatiana V KirichenkoGjumrakch Aliev
Apr 1, 2020·Journal of the American Heart Association·Alinda G VosUNKNOWN Ndlovu Research Consortium*
Oct 28, 2019·International Journal of Environmental Research and Public Health·Grzegorz Józef NowickiEwa Rudnicka-Drożak
Nov 30, 2019·International Angiology : a Journal of the International Union of Angiology·Luca SabaJasjit S Suri
Nov 1, 2020·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Marta Leńska-MieciekJacek Sobocki
Mar 30, 2021·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Nida ÖztopAslı Gelincik

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Methods Mentioned

BETA
imaging techniques
CLAS

Software Mentioned

METEOR

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