PMID: 16628337Apr 22, 2006Paper

Carotid plaque morphologic characteristics

Perspectives in Vascular Surgery and Endovascular Therapy
Gilbert AidinianAnton N Sidawy

Abstract

Carotid artery atherosclerosis is predominantly believed to mirror atherosclerosis elsewhere in the body. Endothelial injury results in expression of cell surface adhesion molecules with expression of sequence of genes involved in the inflammatory pathway and expression of proinflammatory cytokines. The combination of the inflammatory mediators and contribution by monocytes infiltrating the intima and vascular smooth muscle cell proliferation result in the development of atheromatous plaque with a lipid-rich necrotic core. Complications of these atheromatous plaques can lead to plaque instability, rupture, and subsequent hemorrhage or ulceration. The significant risk factors, characteristics associated with symptoms, and available diagnostic imaging modalities are also discussed with review of the relevant literature.

Citations

Jan 20, 2016·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Tatiana V KirichenkoAlexander N Orekhov
Jul 14, 2010·ANZ Journal of Surgery·Manar KhashramDavid R Lewis
May 23, 2020·Cardiovascular and Interventional Radiology·Miklós VértesEdit Dósa
Aug 31, 2007·FEMS Immunology and Medical Microbiology·Jürgen RödelEberhard Straube

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