Carotid sinus syndrome, should we pace? A multicentre, randomised control trial (Safepace 2)

Heart
Daniel J RyanKenny Roseanne

Abstract

Cardioinhibitory carotid sinus hypersensitivity (CICSH) is highly prevalent among older people with falls. To assess the efficacy of dual-chamber pacing in older patients with CICSH and unexplained falls. A multicentre, double blind, randomised controlled trial. Selection from emergency room, geriatric medicine and orthopaedic departments. Patients aged >50 years, with two unexplained falls and/or one syncopal event in the previous 12 months for which no other cause is evident apart from CICSH. Patients randomised to either a 700/400 kappa, rate responsive pacemaker or implantable loop recorder (Medtronic Reveal thera RDR, Medtronic, Minneapolis, Minnesota, USA). The primary outcome was the number falls after implantation. Secondary outcomes were time to fall event, presyncope, quality of life and cognitive function. 141 patients were recruited from 22 centres. Mean age was 78 years and mean follow-up 24 months. The overall relative risk of falling after device implantation compared with before was 0.23 (0.15 to 0.32). No significant reduction in falls was seen between paced and loop recorder groups (RR=0.79; 95% CI 0.41 to 1.50). Data were also consistent in both groups for syncope, quality of life and cognitive function. Conc...Continue Reading

Citations

Nov 23, 2010·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·C T P Paul KredietWouter Wieling
Dec 21, 2010·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Ricardo LopesMaria Júlia Maciel
Mar 31, 2011·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Michele Brignole, Carlo Menozzi
Sep 22, 2012·ISRN Cardiology·Alfonso LagiSimone Cencetti
Apr 1, 2014·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Bing-Wei ChenAi-Min Dang
Nov 19, 2014·Global Cardiology Science & Practice·Richard Sutton
Mar 29, 2014·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Maggi RobertoUngar Andrea
Mar 12, 2013·Progress in Cardiovascular Diseases·Steve W Parry, Iain G Matthews
Dec 14, 2011·Revista Portuguesa De Cardiologia : Orgão Oficial Da Sociedade Portuguesa De Cardiologia = Portuguese Journal of Cardiology : an Official Journal of the Portuguese Society of Cardiology·Reginald Liew
Nov 26, 2010·International Journal of Cardiology·V K MarrisonS W Parry
Oct 12, 2010·Clinics in Geriatric Medicine·Hilary Cronin, Rose Anne Kenny
May 3, 2012·Pacing and Clinical Electrophysiology : PACE·Christopher J McLeodWin-Kuang Shen
Jun 28, 2015·Cardiology Clinics·Venkata Krishna PuppalaDavid G Benditt
Jun 28, 2015·Cardiology Clinics·Iain G MatthewsSteve W Parry
Jan 11, 2014·Journal of cardiology·Venkata Krishna PuppalaDavid G Benditt
Feb 18, 2015·Current Problems in Cardiology·Kathleen WalshMohamed H Hamdan
Jul 23, 2016·Neurologic Clinics·Inna Kleyman, Louis H Weimer
Oct 6, 2016·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Roman BrennerMichael Kühne
Jun 21, 2014·Journal of the American Heart Association·Maw Pin TanSteve W Parry
Feb 26, 2019·Journal of Arrhythmia·Antonio BisignaniGiovanni Bisignani
Apr 2, 2019·The Journal of Nutrition, Health & Aging·S LuitingN van der Velde
Sep 14, 2012·The Cochrane Database of Systematic Reviews·Lesley D GillespieSarah E Lamb
Sep 12, 2014·Cardiology in Review·Vaibhav Amin, Behzad B Pavri
Oct 7, 2011·The Cochrane Database of Systematic Reviews·Jacobus Jcm RommeNynke Van Dijk
Mar 22, 2018·European Heart Journal·Michele BrignoleUNKNOWN ESC Scientific Document Group
Dec 14, 2018·Expert Review of Medical Devices·Rafi SakhiSing-Chien Yap
May 12, 2020·Frontiers in Cardiovascular Medicine·Steve W Parry
Apr 26, 2012·Pacing and Clinical Electrophysiology : PACE·Franco GiadaAntonio Raviele
Dec 20, 2017·Journal of Arrhythmia·Richard Sutton

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Related Papers

Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology
C T P Paul KredietWouter Wieling
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