Abstract
The purpose of this study was to investigate the dosimetric benefits and treatment efficiency of carotid-sparing TomoHelical 3-dimensional conformal radiotherapy (TH-3DCRT) for early glottic cancer. Ten early-stage (T1N0M0) glottic squamous cell carcinoma patients were simulated, based on computed tomography scans. Two-field 3DCRT (2F-3DCRT), 3-field intensity-modulated radiation therapy (3F-IMRT), TomoHelical-IMRT (TH-IMRT), and TH-3DCRT plans were generated with a 67.5-Gy total prescription dose to the planning target volume (PTV) for each patient. In order to evaluate the plan quality, dosimetric characteristics were compared in terms of conformity index (CI) and homogeneity index (HI) for PTV, dose to the carotid arteries, and maximum dose to the spinal cord. Treatment planning and delivery times were compared to evaluate treatment efficiency. The median CI was substantially better for the 3F-IMRT (0.65), TH-IMRT (0.64), and TH-3DCRT (0.63) plans, compared to the 2F-3DCRT plan (0.32). PTV HI was slightly better for TH-3DCRT and TH-IMRT (1.05) compared to 2F-3DCRT (1.06) and 3F-IMRT (1.09). TH-3DCRT, 3F-IMRT, and TH-IMRT showed an excellent carotid sparing capability compared to 2F-3DCRT (p < 0.05). For all plans, the maximu...Continue Reading
References
May 1, 1990·The American Journal of Physiology·R O DantasI M Lang
Jan 1, 1990·International Journal of Radiation Oncology, Biology, Physics·T TeshimaT Inoue
Nov 14, 1997·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·M ChataniT Inoue
Jun 6, 2000·Dysphagia·R J LeonardA Walker
Jan 5, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lucille D A DorresteijnHarry Bartelink
May 10, 2003·International Journal of Radiation Oncology, Biology, Physics·Bram van AsselenChris H J Terhaard
Jun 28, 2005·International Journal of Radiation Oncology, Biology, Physics·Joseph D MartinJohn H Hay
Sep 20, 2005·International Journal of Radiation Oncology, Biology, Physics·Paul D BrownJohn W Hallett
Aug 30, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Grace L SmithDavid I Rosenthal
Jun 16, 2009·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Sarah O S OsmanPeter C Levendag
Aug 15, 2009·International Journal of Radiation Oncology, Biology, Physics·David I RosenthalK Kian Ang
Nov 28, 2009·International Journal of Radiation Oncology, Biology, Physics·Bhishamjit S CheraWilliam M Mendenhall
Mar 2, 2010·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Anders BertelsenCarsten Brink
Aug 28, 2010·Radiation Oncology·Daniel GomezNancy Lee
Dec 17, 2010·Medical Physics·Laurence E CourtTania Lingos
Jan 1, 2006·Biomedical Imaging and Intervention Journal·Ky Cheung
Jun 15, 2011·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Peter C LevendagSarah O S Osman
Aug 21, 2012·Medical Dosimetry : Official Journal of the American Association of Medical Dosimetrists·Adam C RiegelDavid L Schwartz
Jul 25, 2013·Acta Oncologica·Sarah O S OsmanBen J M Heijmen
Oct 16, 2013·Journal of Cancer Research and Therapeutics·Sanjoy ChatterjeeRimpa Achari
Jul 1, 2011·Practical Radiation Oncology·Benedick A FraassUNKNOWN ASTRO Multidisciplinary Quality Assurance Subcommittee
Jul 1, 2011·Practical Radiation Oncology·Jean M MoranLawrence B Marks
Citations
Apr 23, 2016·Radiation Oncology Journal·Hoon Sik ChoiKi Mun Kang
Jan 5, 2019·Health Physics·Razzagh Abedi FirouzjahMohsen Bakhshandeh
Dec 21, 2019·Radiation Oncology·Chae-Seon HongHo Lee
Oct 10, 2020·Technology in Cancer Research & Treatment·Yurday OzdemirErkan Topkan
Dec 5, 2020·International Journal of Particle Therapy·Takahiro KatoMasao Murakami