Carotid versus coronary atherosclerosis burdens in acute compared with chronic symptomatic coronary artery disease

Canadian Journal of Physiology and Pharmacology
Stéphanie LeBlancEric Larose

Abstract

Prediction of coronary events remains elusive. Carotid atherosclerosis may be a surrogate for coronary risk, as carotid and coronary diseases occur simultaneously - albeit at times with a weak association - depending on clinical presentation. We investigated carotid and coronary atherosclerosis in men with new-onset unstable coronary artery disease (CAD) presenting with acute ST-segment elevation myocardial infarction (STEMI) vs. long-standing severe chronic stable angina (CSA). Bilateral carotid artery and 3-vessel coronary artery atherosclerosis burdens were measured within 1 month, respectively, by 3D-volumetric carotid magnetic resonance imaging and coronary angiography-derived modified CASS-50 score. Men with STEMI (n = 50) and long-standing CSA (n = 50), matched for age, were enrolled (58.6 ± 8.8 years). All of them had carotid atherosclerosis. Atherosclerosis burden was greater in the carotid arteries of STEMI vs. CSA (wall volume: 196.2 ± 44.4 vs. 169.2 ± 38.0 mm(3)/4 mm, p = 0.002), but greater in the coronary arteries of CSA vs. STEMI (modified CASS-50 score: 3 vs. 1, p < 0.0001). Normalized wall index (NWI) of internal carotid was associated with modified CASS-50 score in STEMI (ρ = 0.40, p = 0.022) and in CSA (ρ = -...Continue Reading

References

May 28, 1987·The New England Journal of Medicine·S GlagovG J Kolettis
Apr 1, 1996·Stroke; a Journal of Cerebral Circulation·C Bonithon-KoppP Ducimetière
Aug 6, 1999·Stroke; a Journal of Cerebral Circulation·K Jensen-UrstadJ Johansson
Jul 18, 2003·The American Journal of Medicine·Cheryl K NordstromJames H Dwyer
Jun 10, 2006·Stroke; a Journal of Cerebral Circulation·Ji-Guang WangMichel Safar
Mar 27, 2007·JAMA : the Journal of the American Medical Association·John R CrouseUNKNOWN METEOR Study Group
Sep 25, 2007·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Loic BousselPhilippe Charles Douek
Jan 1, 2008·JAMA : the Journal of the American Medical Association·David M LarsonTimothy D Henry
Jan 24, 2008·Circulation·Ralph B D'AgostinoWilliam B Kannel
Jun 14, 2008·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Hunter R UnderhillJohn R Crouse
Aug 22, 2008·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Micaela EggerGrace Parraga
Apr 28, 2009·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Venkatesh ManiZahi A Fayad
Jul 22, 2009·American Heart Journal·Shaun G GoodmanUNKNOWN Expanded Global Registry of Acute Coronary Events (GRACE2) Investigators
Oct 8, 2009·Circulation. Cardiovascular Imaging·R DuivenvoordenA J Nederveen
Nov 17, 2009·The New England Journal of Medicine·Allen J TaylorMark Turco
Jan 23, 2010·AJNR. American Journal of Neuroradiology·H R UnderhillC Yuan
Apr 24, 2010·Stroke; a Journal of Cerebral Circulation·J David Spence, Daniel G Hackam
Jul 2, 2010·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Feiyu LiChun Yuan
Jul 3, 2010·Stroke; a Journal of Cerebral Circulation·Dionesia D AdraktasMax Wintermark
Dec 29, 2010·The American Journal of Medicine·David D McManusRobert J Goldberg
Mar 29, 2011·Current Problems in Diagnostic Radiology·Eugene LinWayne Hwang
Jun 12, 2012·Atherosclerosis·Augusto GallinoPeter Libby
Oct 17, 2012·American Heart Journal·Ian J NeelandArshed A Quyyumi
Dec 12, 2012·Atherosclerosis·Fisnik JashariMichael Y Henein

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