Carriage of Clostridium difficile in outpatients with irritable bowel syndrome

Journal of Medical Microbiology
Evelyn M ClaytonColin Hill

Abstract

Irritable bowel syndrome (IBS) is a common, typically chronic and sometimes disabling gastrointestinal condition of uncertain aetiology. Recently, a variety of links to gastrointestinal infections have been described including the onset of IBS following exposure to enteric pathogens and an apparent predisposition to gastrointestinal infection. The prevalence of Clostridium difficile in a population of IBS outpatients (n = 87) in the absence of established risk factors for the acquisition of C. difficile infection was examined. Overall, 5.7 % of patients (n = 5) carried culturable C. difficile and 4.6 % (n = 4) of isolates were toxigenic, belonging to toxinotype group 0, compared with 1.1 % (n = 1) for the healthy control group (n = 88). These isolates were members of toxigenic PCR ribotype groups 005 and 050 (IBS group) and 062 (control group) and were identified further as three individual strains by PFGE. Although no significant difference was observed between IBS patients and healthy volunteers, these findings support the concept that a subpopulation of IBS patients may be susceptible to gastrointestinal infection.

References

May 15, 1989·The Medical Journal of Australia·T J BorodyD Moore-Jones
Sep 1, 1988·Infection and Immunity·M R PopoffP Boquet
Feb 1, 1985·Infection and Immunity·D M LyerlyT D Wilkins
Jan 11, 2001·The American Journal of Gastroenterology·M PimentelH C Lin
Oct 19, 2002·International Journal of Antimicrobial Agents·Wafaa Y JamalV O Rotimi
Nov 28, 2002·Gastroenterology·Douglas A DrossmanWilliam E Whitehead
Feb 20, 2003·The American Journal of Gastroenterology·Robin C Spiller
Apr 3, 2003·Journal of Bacteriology·P J SimpsonR P Ross
Jan 26, 2005·The American Journal of Gastroenterology·Erja MalinenAiri Palva
Jan 28, 2006·World Journal of Gastroenterology : WJG·Eamonn M M Quigley
Feb 4, 2006·The American Journal of Gastroenterology·Ala I ShararaIhab Elhajj
Dec 28, 2006·Scandinavian Journal of Gastroenterology·Fredrik HjernClaes Johansson
Jan 24, 2007·Journal of Gastroenterology·Robin C Spiller
Sep 14, 2007·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·F BarbutUNKNOWN European Study Group on Clostridium difficile (ESGCD)
Jun 3, 2008·The American Journal of Gastroenterology·Gareth C ParkesJeremy D Sanderson

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Citations

Jun 4, 2014·Global Advances in Health and Medicine : Improving Healthcare Outcomes Worldwide·Julius GoeppDarryl Landis
Jun 4, 2014·Global Advances in Health and Medicine : Improving Healthcare Outcomes Worldwide·Kelly ParsonsDarryl Landis
Jul 31, 2013·Letters in Applied Microbiology·M M O' DonnellR P Ross
Feb 27, 2016·International Journal of Medical Microbiology : IJMM·Ying-Chen WuTer-Hsin Chen
Oct 16, 2019·Antimicrobial Agents and Chemotherapy·Brindar K SandhuShonna M McBride
Dec 30, 2017·Cellular and Molecular Life Sciences : CMLS·Gabrio BassottiKatia Fettucciari

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