Carriage of encapsulated bacteria in Gabonese children with sickle cell anaemia

Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases
Frieder SchaumburgA A Adegnika

Abstract

Sickle cell anaemia (SCA) is a haemoglobin disorder that alters the deformability of erythrocytes through abnormal polymerization of haemoglobin. Children with SCA have an increased risk of infections with encapsulated bacteria. To guide the antibiotic prophylaxis and vaccinations in children with SCA in Gabon, we characterized Streptococcus pneumoniae, Staphylococcus aureus and Haemophilus influenzae from children with and without SCA. We performed a cross-sectional study and compared nasal and pharyngeal S. pneumoniae, Staph. aureus and H. influenzae isolates from SCA children (n = 73) with comparators matched for age, residence and sex (n = 143) in a matched-comparison analysis. The resistance pattern and capsular type were identified for each isolate. The total carriage rate for S. pneumoniae, Staph. aureus and H. influenzae was 13.8%, 46.7% and 12.5%, respectively, and did not differ between groups (p >0.05). The mean number of days under antibiotic treatment in the past year was higher in children with SCA than in controls (penicillin: 70.1 vs 0.1 days, p 0.00002). The total non-susceptibility rate was 30% for oral and parenteral (meningitis) penicillin in S. pneumoniae, resistance rates were 1.6% for oxacillin in Staph. ...Continue Reading

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Citations

Jun 27, 2014·Archives of Oral Biology·Bruno Mello de MatosCristiane Yumi Koga-Ito
May 28, 2014·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·F SchaumburgK Becker
Mar 25, 2015·The American Journal of Tropical Medicine and Hygiene·Gaël MourembouDidier Raoult
Apr 5, 2013·The Pediatric Infectious Disease Journal·Lilly M VerhagenPeter W M Hermans
May 10, 2020·BioMed Research International·Wafa F S BadullaMohamed Izham Mohamed Ibrahim

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