Abstract
Sickle cell anaemia (SCA) is a haemoglobin disorder that alters the deformability of erythrocytes through abnormal polymerization of haemoglobin. Children with SCA have an increased risk of infections with encapsulated bacteria. To guide the antibiotic prophylaxis and vaccinations in children with SCA in Gabon, we characterized Streptococcus pneumoniae, Staphylococcus aureus and Haemophilus influenzae from children with and without SCA. We performed a cross-sectional study and compared nasal and pharyngeal S. pneumoniae, Staph. aureus and H. influenzae isolates from SCA children (n = 73) with comparators matched for age, residence and sex (n = 143) in a matched-comparison analysis. The resistance pattern and capsular type were identified for each isolate. The total carriage rate for S. pneumoniae, Staph. aureus and H. influenzae was 13.8%, 46.7% and 12.5%, respectively, and did not differ between groups (p >0.05). The mean number of days under antibiotic treatment in the past year was higher in children with SCA than in controls (penicillin: 70.1 vs 0.1 days, p 0.00002). The total non-susceptibility rate was 30% for oral and parenteral (meningitis) penicillin in S. pneumoniae, resistance rates were 1.6% for oxacillin in Staph. ...Continue Reading
References
Sep 1, 1993·The Pediatric Infectious Disease Journal·M E SchrickerB Berman
Jan 4, 2001·The New England Journal of Medicine·C von EiffG Peters
Feb 15, 2002·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·R N Davidson, R A Wall
Feb 15, 2003·The Pediatric Infectious Disease Journal·Katherine L O'BrienUNKNOWN World Health Organization Pneumococcal Vaccine Trials Carriage Working Group
Aug 28, 2003·JAMA : the Journal of the American Medical Association·Colin M SoxDimitri A Christakis
Mar 5, 2004·The Lancet Infectious Diseases·D BogaertP W M Hermans
Jun 9, 2004·Lancet·D BogaertP W M Hermans
Nov 6, 2004·Journal of Clinical Microbiology·Karsten BeckerChristof von Eiff
Mar 15, 2006·Archives of Disease in Childhood·M E KizitoG R Serjeant
Dec 8, 2006·The Journal of Infectious Diseases·Timothy F MurphyAlan J Lesse
Dec 29, 2007·The Pediatric Infectious Disease Journal·Osman AbdullahiJ Anthony G Scott
Sep 2, 2008·International Journal of Antimicrobial Agents·Adam C Schaffer, Jean C Lee
Sep 20, 2008·Vaccine·Bradford D Gessner, Richard A Adegbola
Nov 13, 2008·Pediatric Radiology·Rana KhatibSharada A Sarnaik
Sep 15, 2009·Lancet·Thomas N WilliamsJ Anthony G Scott
Apr 27, 2010·The Lancet Infectious Diseases·Meenakshi RamakrishnanOrin S Levine
Jun 30, 2010·Antimicrobial Agents and Chemotherapy·Darlington M MwenyaStephen H Gillespie
Aug 3, 2010·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·S BreurecF Laurent
Nov 4, 2010·Nature Communications·Frédéric B PielSimon I Hay
May 21, 2011·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·F SchaumburgK Becker
Citations
Oct 3, 2013·BMC Infectious Diseases·Abraham S AlabiFrieder Schaumburg
Jun 27, 2014·Archives of Oral Biology·Bruno Mello de MatosCristiane Yumi Koga-Ito
May 28, 2014·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·F SchaumburgK Becker
Feb 24, 2015·Frontiers in Microbiology·Christian KraefFrieder Schaumburg
Mar 25, 2015·The American Journal of Tropical Medicine and Hygiene·Gaël MourembouDidier Raoult
Nov 9, 2018·PloS One·Nicholas T K D DayieEric S Donkor
Apr 5, 2013·The Pediatric Infectious Disease Journal·Lilly M VerhagenPeter W M Hermans
May 2, 2020·Pathogens·Vera A AppiahEric S Donkor
May 10, 2020·BioMed Research International·Wafa F S BadullaMohamed Izham Mohamed Ibrahim