Carriage of Streptococcus pneumoniae in aged adults with influenza-like-illness

PloS One
Cassandra L KroneKrzysztof Trzciński

Abstract

Incidence of pneumococcal disease is disproportionally high in infants and elderly. Nasopharyngeal colonisation by Streptococcus pneumoniae is considered a prerequisite for disease but unlike in children, carriage in elderly is rarely detected. Here, we tested for S. pneumoniae in nasopharyngeal and saliva samples collected from community-dwelling elderly with influenza-like-illness (ILI). Trans-nasal nasopharyngeal, trans-oral nasopharyngeal and saliva samples (n = 270 per sample type) were collected during winter/spring 2011/2012 from 135 persons aged 60-89 at onset of ILI and 7-9 weeks later following recovery. After samples were tested for pneumococci by conventional culture, all plate growth was collected. DNA extracted from plate harvests was tested by quantitative-PCRs (qPCR) specific for S. pneumoniae and serotypes included in the 13-valent pneumococcal conjugated vaccine (PCV13). Pneumococci were cultured from 14 of 135 (10%) elderly with none of the sampled niches showing superiority in carriage detection. With 76/270 (28%) saliva, 31/270 (11%) trans-oral and 13/270 (5%) trans-nasal samples positive by qPCR, saliva was superior to nasopharyngeal swabs (p<0.001) in qPCR-based carriage detection. Overall, from all metho...Continue Reading

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Citations

Dec 18, 2015·Current Opinion in Microbiology·Kimberly A Kline, Dawn M E Bowdish
Jan 19, 2016·Current Opinion in Infectious Diseases·Catia CillónizAntoni Torres
Jan 14, 2016·Immunity & Ageing : I & a·Susanna EspositoNicola Principi
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Aug 29, 2021·Pathogens·Lisa J M SlimmenWendy W J Unger

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