Carrier-mediated jejunal absorption of conjugated bile acids in the guinea pig

Gastroenterology
A AmelsbergA F Hofmann

Abstract

Conjugated bile acid absorption is known to occur in the jejunum in mammals, but the mechanism has not been well defined. The aim of this study was to define the mechanisms by which conjugated bile acids are absorbed from the jejunum. The steady-state absorption of eight conjugated bile acids from a perfused jejunal segment was measured in the anesthetized biliary fistula guinea pig. Experiments defined the effect of bile acid structure, tested for competitive inhibition and saturation of transport, and compared the absorption rate of taurine conjugates with that of glycine conjugates at pH 7.6 or 5.0. Dihydroxy conjugates were absorbed twice as rapidly as cholyl conjugates from the perfused jejunum; glycine and taurine conjugates of a given bile acid were absorbed at a similar rate. Absorption of ursodeoxycholate taurine showed saturability and competitive inhibition by other conjugated bile acids. When intraluminal pH was decreased to pH 5.0, the absorption rate of glycine (but not taurine) conjugates increased, indicating passive absorption of the protonated species of glycine-conjugated bile acids. Uptake of glycine- or taurine-conjugated bile acids by the guinea pig jejunum occurs by at least two mechanisms: carrier-mediat...Continue Reading

Citations

Nov 26, 1998·JPEN. Journal of Parenteral and Enteral Nutrition·J C Hall
Jun 30, 1998·Current Opinion in Lipidology·M W Love, P A Dawson
Mar 10, 1999·The American Journal of Physiology·A AmelsbergU R Fölsch
Nov 30, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·H C WaltersP A Dawson
Dec 25, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·Xianyong Gui, Robert E Carraway
Aug 20, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ulrich BeuersRonald P J Oude Elferink
Oct 21, 2019·The Journal of Clinical Endocrinology and Metabolism·Andreas Brønden, Filip K Knop
Jul 9, 2002·Journal of Gastroenterology and Hepatology·Toshiki OnishiHajime Takikawa
Mar 21, 1998·Journal of Gastroenterology and Hepatology·H TakikawaM Yamanaka
Jun 9, 2001·Journal of Pediatric Gastroenterology and Nutrition·B L Shneider
Jun 6, 2009·Journal of Lipid Research·Paul A DawsonAnuradha Rao
Feb 5, 2002·Annual Review of Physiology·Peter J Meier, B Stieger
Oct 31, 2007·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·H Lennernäs
Sep 21, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Simon HohenesterUlrich Beuers
Feb 14, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S CeryakH Fromm
Jun 26, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·Takahiro ShojiYuichi Sugiyama
Jun 24, 2003·The Journal of Biological Chemistry·Paul A DawsonJohn S Parks
Aug 2, 2011·Current Gastroenterology Reports·Ian JohnstonJulian R F Walters
Sep 12, 2014·Journal of Lipid Research·Paul A Dawson, Saul J Karpen
Nov 14, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·X GuiR E Carraway
Jun 17, 2000·Biochimica Et Biophysica Acta·L B Agellon, E C Torchia
Dec 31, 2003·Gastroenterology·Gerd A Kullak-UblickPeter J Meier
Jun 6, 2006·Molecular Pharmaceutics·Anand Balakrishnan, James E Polli

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.