Carriers for the targeted delivery of aerosolized macromolecules for pulmonary pathologies

Expert Opinion on Drug Delivery
Nashwa OsmanImran Saleem

Abstract

Macromolecules with unique effects and potency are increasingly being considered for application in lung pathologies. Numerous delivery strategies for these macromolecules through the lung have been investigated to improve the targeting and overall efficacy. Targeting approaches from delivery devices, formulation strategies and specific targets are discussed. Although macromolecules are a heterogeneous group of molecules, a number of strategies have been investigated at the macro, micro, and nanoscopic scale for the delivery of macromolecules to specific sites and cells of lung tissues. Targeted approaches are already in use at the macroscopic scale through inhalation devices and formulations, but targeting strategies at the micro and nanoscopic scale are still in the laboratory stage. The combination of controlling lung deposition and targeting after deposition, through a combination of targeting strategies could be the future direction for the treatment of lung pathologies through the pulmonary route.

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Citations

Jul 10, 2019·Expert Opinion on Drug Delivery·Ah Young LeeSanghwa Kim
Sep 11, 2019·Nanotoxicology·Nashwa M OsmanImran Y Saleem
Mar 5, 2020·Expert Opinion on Drug Delivery·Mario CazzolaPaola Rogliani
Mar 7, 2020·Expert Opinion on Drug Delivery·Larissa Gomes Dos Reis, Daniela Traini
Jan 9, 2021·Expert Opinion on Drug Delivery·Maria Gabriella MateraMario Cazzola
Nov 6, 2020·International Journal of Pharmaceutics·Yamini DhayanandamoorthyRuckmani Kandasamy
Oct 24, 2020·American Journal of Respiratory Cell and Molecular Biology·Zicheng DengVladimir V Kalinichenko
Mar 2, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Dina M SilvaVitor Sencadas
Apr 1, 2021·Journal of Biomaterials Science. Polymer Edition·Md Mohosin Rana
Apr 1, 2021·Life Sciences·Pragya PrasannaSulakshana Sulakshana
Apr 17, 2021·Cancer Gene Therapy·Vijayata SinghGiridhara R Jayandharan
Jul 3, 2021·Polymers·Teresa BasinskaStanislaw Slomkowski
Jan 12, 2021·Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society·Xue JinShui Yu

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Methods Mentioned

BETA
transfection

Clinical Trials Mentioned

NCT01712334
NCT01684410

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