Cart overexpression is the only identifiable cause of high bone mass in melanocortin 4 receptor deficiency

Endocrinology
Jong Deok AhnGerard Karsenty

Abstract

The neural regulation of bone remodeling has proven to be increasingly complex at the molecular level because it involves both positive and negative mediators of bone formation and resorption. One of the mediators expressed in hypothalamic neurons that leptin uses to inhibit osteoclast differentiation and thereby bone resorption is cocaine- and amphetamine-regulated transcript (CART). CART expression in the hypothalamus is increased in mice lacking melanocortin 4 receptor (Mc4r(-/-) mice). Moreover, we show here that humans or mice lacking only one allele of Mc4r display a decrease in bone resorption parameters, high bone mass, and an increase in CART serum levels and/or hypothalamic expression. To demonstrate that the Cart overexpression is the only identifiable cause for the high bone mass observed upon Mc4r inactivation, we removed one allele of Cart from mice either heterozygous or homozygous for Mc4r inactivation. This manipulation sufficed to either significantly improve or normalize bone resorption parameters, without improving the energy metabolism disturbance that characterizes Mc4r-deficient mice. These results identify CART signaling as the main if not only molecular pathway accounting for the decrease in bone resorp...Continue Reading

References

Dec 1, 1987·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·A M ParfittR R Recker
May 20, 1998·Nature·P KristensenS Hastrup
Mar 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·L ThimJ T Clausen
Jun 8, 1999·The Journal of Biological Chemistry·A J ChruscinskiB K Kobilka
Jul 21, 2000·The Journal of Clinical Investigation·C VaisseP Froguel
Jul 21, 2000·The Journal of Clinical Investigation·I S FarooqiS O'Rahilly
Mar 10, 2001·The Journal of Comparative Neurology·C F EliasJ K Elmquist
Jun 20, 2002·Proceedings of the National Academy of Sciences of the United States of America·Amanda SainsburyHerbert Herzog
Nov 7, 2002·Cell·Shu TakedaGerard Karsenty
Dec 25, 2002·Human Molecular Genetics·Cecile Lubrano-BerthelierChristian Vaisse
Apr 12, 2003·The Journal of Biological Chemistry·Wouter A J NijenhuisRoger A H Adan
Jan 20, 2004·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·N WierupF Sundler
May 6, 2004·The Journal of Clinical Endocrinology and Metabolism·Cécile Lubrano-BerthelierChristian Vaisse
Feb 23, 2005·Nature·Florent ElefteriouGerard Karsenty
Sep 7, 2005·Cell·Loning FuGerard Karsenty

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Citations

Apr 19, 2007·Calcified Tissue International·M S Patel, F Elefteriou
Sep 18, 2007·Nature Medicine·Shingo SatoShu Takeda
Sep 20, 2008·Nature Reviews. Neuroscience·G RoggeM J Kuhar
Aug 3, 2007·Proceedings of the National Academy of Sciences of the United States of America·Dana C DolinoyRandy L Jirtle
May 11, 2012·Proceedings of the National Academy of Sciences of the United States of America·Benjamin J RenquistRoger D Cone
May 13, 2010·American Journal of Physiology. Endocrinology and Metabolism·Niamh X CawleyY Peng Loh
Aug 24, 2011·Annals of Nutrition & Metabolism·Patrick Tounian
Mar 10, 2012·Endocrine Reviews·Niamh X CawleyY Peng Loh
Jul 9, 2010·The Journal of Clinical Endocrinology and Metabolism·Dominique N LongEmily L Germain-Lee
Sep 19, 2006·Drugs·Sara P ModjtahediIgal Leibovitch
Feb 2, 2012·International Journal of Molecular Medicine·Jun MizutaniTakanobu Otsuka
Sep 27, 2014·Best Practice & Research. Clinical Endocrinology & Metabolism·Kunal Sharan, Vijay K Yadav
Nov 15, 2011·Annual Review of Physiology·Gerard Karsenty, Franck Oury
Jun 21, 2014·Archives of Biochemistry and Biophysics·Isabel Quiros-Gonzalez, Vijay K Yadav
Jun 3, 2010·Archives of Biochemistry and Biophysics·Jianwen Wei, Patricia Ducy
Oct 11, 2015·Bone·Peter HouwelingPaul A Baldock
Sep 15, 2009·Neuropeptides·Nicola J Lee, Herbert Herzog
Apr 21, 2009·Molecular and Cellular Endocrinology·Cyrille B ConfavreuxGerard Karsenty
Sep 2, 2008·Seminars in Cell & Developmental Biology·Iris P L WongPaul A Baldock
Nov 8, 2015·Bone·Natalie K Y WeePaul A Baldock
May 23, 2007·The Journal of Pediatrics·Béatrice DubernKarine Clément
Dec 13, 2006·Best Practice & Research. Clinical Endocrinology & Metabolism·David M Mutch, Karine Clément
Apr 15, 2015·Menopause : the Journal of the North American Menopause Society·Eun Hee ChunJung Gu Kim
Jul 8, 2008·Journal of Neuroendocrinology·S Takeda
Oct 26, 2012·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·M M BrzozowskaJ R Center
Sep 3, 2011·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Han GerritsJan A Gossen
Apr 16, 2008·Archives of Biochemistry and Biophysics·Florent Elefteriou
May 28, 2010·The Biochemical Journal·Kathleen G Mountjoy
Jan 8, 2008·Cell Metabolism·Clifford J Rosen
Dec 4, 2014·Medical Hypotheses·Maria-Cristina PorfirioDiane Purper-Ouakil
Mar 30, 2018·The Journal of Clinical Investigation·Anna IdelevichRoland Baron
Sep 1, 2019·Journal of Bone and Mineral Metabolism·Eva W IepsenSigne S Torekov
Oct 28, 2019·Bone Research·Jian LuoJianru Xiao
Mar 1, 2015·Expert Review of Endocrinology & Metabolism·Alessia MetozziMaria Luisa Brandi
Nov 1, 2009·Expert Review of Endocrinology & Metabolism·Apostolos I GogakosGraham R Williams
Nov 17, 2017·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·A QasimD Meyre
Jan 30, 2020·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Anna IdelevichRoland Baron
Aug 10, 2016·Calcified Tissue International·Paul Dimitri, Cliff Rosen
Apr 30, 2021·Journal of Neuroendocrinology·Ronaldo F EnriquezHerbert Herzog

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