PMID: 11329127May 1, 2001Paper

CART peptide-immunoreactive projection from the nucleus accumbens targets substantia nigra pars reticulata neurons in the rat

The Journal of Comparative Neurology
S Dallvechia-AdamsM J Kuhar

Abstract

Cocaine and amphetamine regulated transcript (CART) was originally identified as a mRNA which increases in the striatum after acute cocaine or amphetamine administration in rats. In addition, intra-ventral tegmental (VTA) area injections of CART peptides produce psychostimulant-like behavioral effects. CART peptide immunoreactivity (CARTir) has been localized in discrete nuclei throughout the brain, and, within the striatum, it is located only ventrally in a subpopulation of medium spiny projection neurons in the shell and core of the nucleus accumbens. To better understand the potential role of CART peptides in the mechanism of action of psychomotor stimulants, we analyzed the distribution and synaptic connectivity of CARTir terminals in the ventral midbrain. CARTir terminal-like varicosities were located throughout the rostrocaudal extent of the substantia nigra (SN), VTA, and retrorubral field (RRF). They were particularly abundant in the dorsomedial SN where they overlapped with non-dopaminergic substantia nigra pars reticulata (SNr) neurons and proximal dendrites of dopaminergic substantia nigra pars compacta (SNc) neurons. CARTir terminals were also in register with dopaminergic perikarya in the ventromedial part of the r...Continue Reading

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Citations

Jun 13, 2003·Life Sciences·J N JaworskiM J Kuhar
Aug 14, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Susan R Sesack, Anthony A Grace
May 15, 2013·Zhurnal evoliutsionnoĭ biokhimii i fiziologii·I V Romanova
Jan 29, 2014·Peptides·Nishikant K SubhedarDadasaheb M Kokare
Jul 1, 2008·Neuroscience and Biobehavioral Reviews·Roberto CoccurelloAnna Moles
Jul 17, 2004·Regulatory Peptides·Yang-Ho ChoiClifton A Baile
Jun 9, 2006·Peptides·Kelly Philpot, Yoland Smith
Jun 28, 2005·Brain Research·George W Hubert, Michael J Kuhar
Jan 15, 2015·Neuroscience·S Liu, S L Borgland
Jul 31, 2002·Neuropeptides·M J KuharB Balkan
Apr 2, 2013·Pharmaceuticals·Peizhong MaoP Hemachandra Reddy
Oct 11, 2003·The Journal of Pharmacology and Experimental Therapeutics·Jason N JaworskiMichael J Kuhar
Nov 19, 2020·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Christopher J HaddockGina L C Yosten
Apr 27, 2020·Brain Research·Zhi Yi Ong, Gavan P McNally

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