Cartducin stimulates mesenchymal chondroprogenitor cell proliferation through both extracellular signal-regulated kinase and phosphatidylinositol 3-kinase/Akt pathways

The FEBS Journal
Hironori AkiyamaTakashi Maeda

Abstract

Cartducin, a paralog of Acrp30/adiponectin, is a secretory protein produced by both chondrogenic precursors and proliferating chondrocytes, and belongs to a novel C1q family of proteins. We have recently shown that cartducin promotes the growth of both mesenchymal chondroprogenitor cells and chondrosarcoma-derived chondrocytic cells in vitro. However, the cartducin-signaling pathways responsible for the regulation of cell proliferation have not been documented. In this study, we examined whether cartducin exists in serum and further investigated the intracellular signaling pathways stimulated by cartducin in mesenchymal chondroprogenitor cells. Western blot analysis showed that, unlike Acrp30/adiponectin, cartducin was undetectable in mouse serum. Next, mesenchymal chondroprogenitor N1511 cells were stimulated with cartducin, and three major groups of mitogen-activated protein kinase (MAPK) pathways and the phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway were examined. Cartducin activated extracellular signal-regulated kinase 1/2 (ERK1/2) and Akt, but not c-jun N-terminal kinase (JNK) nor p38 MAPK. The MEK1/2 inhibitor, U0126, blocked cartducin-stimulated ERK1/2 phosphorylation and suppressed the DNA synthesis induce...Continue Reading

References

Nov 10, 1995·The Journal of Biological Chemistry·P E SchererH F Lodish
May 3, 1996·The Journal of Biological Chemistry·E HuB M Spiegelman
Mar 27, 1999·Biochemical and Biophysical Research Communications·Y AritaY Matsuzawa
Jul 27, 1999·The Journal of Biological Chemistry·H Gille, J Downward
Dec 2, 1999·Genes & Development·S R DattaM E Greenberg
Feb 15, 2001·Nature Cell Biology·S M Jones, A Kazlauskas
Oct 9, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Nobuhiro KamiyaHideto Watanabe
Jun 13, 2003·Nature·Toshimasa YamauchiTakashi Kadowaki
Jan 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yutaka NakamuraNizar N Jarjour
Jul 3, 2004·Proceedings of the National Academy of Sciences of the United States of America·Guang W WongHarvey F Lodish
Sep 15, 2004·Trends in Immunology·Uday KishoreGerard J Arlaud

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Citations

Oct 19, 2010·The Journal of Biological Chemistry·Jonathan M PetersonG William Wong
Jun 5, 2007·Current Opinion in Oncology·Warren A Chow
Jun 16, 2014·International Journal of Oral and Maxillofacial Surgery·Z LiZ-B Li
Oct 8, 2013·Hematology/oncology Clinics of North America·Jolieke G van OosterwijkJudith V M G Bovée
Jan 21, 2012·Trends in Endocrinology and Metabolism : TEM·Andreas Schäffler, Christa Buechler
Aug 8, 2007·Trends in Immunology·A SchäfflerB Salzberger
Jul 4, 2015·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Dan WuLi-Ling Wu
Sep 1, 2015·Frontiers in Endocrinology·Thatchawan ThanasupawatThomas Klonisch
Dec 13, 2016·American Journal of Physiology. Lung Cellular and Molecular Physiology·Gianluca TurcatelDavid Warburton
Oct 22, 2010·Endocrinology·Sarah A Compton, Bentley Cheatham
May 31, 2012·Molecular and Cellular Biochemistry·Mi-Jin KimSeung-Yoon Park
Jun 8, 2013·American Journal of Physiology. Gastrointestinal and Liver Physiology·Jonathan M PetersonG William Wong
Dec 7, 2019·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Daniel W YoungstromKurt D Hankenson
May 31, 2007·Molecular and Cellular Biochemistry·Hironori AkiyamaTakashi Maeda
Jun 3, 2011·Archives of Pathology & Laboratory Medicine·Shuting BaiGene P Siegal

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