Cartilage and subchondral bone thickness distribution with MR imaging

Academic Radiology
C A McGibbonD E Krebs

Abstract

The authors mapped articular cartilage (AC) and subchondral bone (SB) thicknesses in human acetabula in vitro by using magnetic resonance (MR) imaging and validated AC measurements by using light microscopy. Left and right acetabula from a deceased patient who had undergone left hemiarthroplasty were imaged with fat-suppressed spoiled gradient-recalled acquisition in the steady state (repetition time = 55 msec, echo time = 15 msec, flip angle = 50 degrees, matrix = 256 x 256, field of view = 8 cm). AC and SB thickness maps were generated from image data by using analytic geometry, which enabled correction for thickness overestimation due to oblique sectioning. Cartilage bone plugs were extracted from the acetabula, and light microscopy was used to validate the thickness measurements obtained with MR imaging. Standard errors between thickness measurements obtained with MR imaging and light microscopy were 0.37 and 0.33 mm for the left and right AC, respectively, which is consistent with the voxel resolution of the MR imaging sequence (0.31 x 0.31 x 0.8 mm). SB thickness of the cartilage plugs could not be reliably measured with light microscopy and, therefore, could not be validated. Contour maps showed that SB thickness gradien...Continue Reading

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Citations

Jan 22, 2000·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J C WatertonC J Taylor
Aug 15, 2003·Magnetic Resonance Imaging Clinics of North America·Robert D Boutin, Joel S Newman
Aug 5, 1998·Medical Engineering & Physics·C A McGibbonD E Krebs
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Sep 6, 2003·IEEE Transactions on Medical Imaging·Yoshinobu SatoShinichi Tamura
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Dec 12, 2019·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Lena K KottmeierMaren Hellige

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