Cartilage atrophy in the knees of patients after seven weeks of partial load bearing

Arthritis and Rheumatism
S HinterwimmerF Eckstein

Abstract

It is currently unknown whether human cartilage properties change during short periods of partial load bearing. We used a post-ankle fracture model to explore whether changes in cartilage morphology occur in the knee under conditions of partial load bearing. The knees of 20 patients with Weber type B and type C fractures were examined using magnetic resonance imaging. The first scan was obtained shortly (mean +/- SD 3.2 +/- 3.0 days) after the injury, and a second scan was obtained 7 weeks later (mean +/- SD 50.7 +/- 5.5 days). The morphology (mean and maximum thickness, volume, and surface area) of the patellar, tibial, and femoral cartilage was determined from coronal and axial magnetic resonance images (fat-suppressed gradient-echo). Between week 0 and week 7, the cross-sectional area of the quadriceps muscle was reduced by 11% (P< 0.001). Changes in the mean (+/-SD) cartilage thickness ranged from -2.9 +/- 3.2% in the patella to -6.6 +/- 4.9% in the medial tibia. No significant change in cartilage morphology of the contralateral knee was observed. Results of this study demonstrate that in a post-ankle fracture model of partial load bearing, cartilage morphology in all knee compartments is subject to significant change. Chan...Continue Reading

References

Aug 1, 1996·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·F EcksteinM Reiser
Jun 1, 2000·Journal of Biomechanics·F EcksteinM Reiser
Nov 17, 2001·Arthritis and Rheumatism·M HudelmaierF Eckstein
Dec 18, 2001·Seminars in Musculoskeletal Radiology·M L GrayY Xia
Sep 5, 2002·Arthritis and Rheumatism·Anita E WlukaFlavia M Cicuttini
Dec 5, 2002·Osteoarthritis and Cartilage·F EcksteinM Reiser
Dec 4, 2003·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Christian GlaserFelix Eckstein
Dec 16, 2003·Arthritis and Rheumatism·B VanwanseeleE Stüssi

❮ Previous
Next ❯

Citations

Dec 19, 2012·Der Unfallchirurg·A PreissK-H Frosch
Sep 13, 2007·Pflügers Archiv : European journal of physiology·J S GibsonR J Wilkins
Aug 23, 2011·Current Osteoporosis Reports·Hiroki YokotaHui B Sun
Sep 3, 2010·Tissue Engineering. Part a·Gian M SalzmannMauro Alini
Aug 3, 2011·Orthopedic Reviews·Christoph ZiskovenRüdiger Krauspe
May 17, 2013·Journal of Athletic Training·Matthew K SeeleyJ Ty Hopkins
Jun 2, 2011·The Journal of Orthopaedic and Sports Physical Therapy·Terese L Chmielewski
Mar 3, 2012·The Journal of Orthopaedic and Sports Physical Therapy·Kai MithoeferStefano Della Villa
Aug 8, 2014·The Journal of Orthopaedic and Sports Physical Therapy·Emily A EismannGregory D Myer
Sep 21, 2013·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Stefan HinterwimmerRüdiger von Eisenhart-Rothe
Jul 29, 2011·Canadian Journal of Physiology and Pharmacology·Christoph ZiskovenRüdiger Krauspe
Dec 2, 2008·Best Practice & Research. Clinical Rheumatology·A J TeichtahlF M Cicuttini
Apr 5, 2007·Journal of Photochemistry and Photobiology. B, Biology·Mohammad BayatAghdas Bayat
Apr 28, 2006·Journal of Anatomy·F EcksteinR Putz
Apr 2, 2009·Scandinavian Journal of Medicine & Science in Sports·Heikki J Helminen
Nov 11, 2010·Annals of the New York Academy of Sciences·Hui B Sun
Oct 28, 2011·The Physician and Sportsmedicine·Graeme JonesDawn Dore
Apr 18, 2016·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Andreas H GomollRene Verdonk
Mar 24, 2015·Journal of Biomechanics·Shannon N EddThomas P Andriacchi
May 15, 2016·Current Rheumatology Reports·Blandine Poulet
Mar 28, 2017·Cartilage·Gian M SalzmannJirí Dvorák
Feb 2, 2017·Exercise and Sport Sciences Reviews·Ross H Miller
Jan 27, 2006·The American Journal of Sports Medicine·Markus A KesslerAndreas B Imhoff
Jul 25, 2017·The American Journal of Sports Medicine·Peter Z DuKristofer J Jones
Mar 3, 2017·The Journal of Rheumatology·Adam El Mongy JørgensenKatja Maria Heinemeier
May 28, 2020·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Anna-Maria LiphardtJoachim Mester
Feb 6, 2017·Nature Reviews. Rheumatology·Peter M van der Kraan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.