Cartilage canals in the chicken embryo are involved in the process of endochondral bone formation within the epiphyseal growth plate

The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology
Michael J F BlumerH Fritsch

Abstract

A detailed study of so-called communicating cartilage canals, which penetrate deeply up into the lower hypertrophic zone of the epiphyseal growth plate in the embryonic chicken femur (E20), was carried out with the aim to clarify whether or not these canals are involved in the bone-forming process. In addition, we examined the manner in which cartilage canals are formed and compare the present data with our previous data. The canals were investigated by means of light microscopy, electron microscopy, immunohistochemistry (VEGF, VEGFR2/Flk1, type I collagen), and 3D reconstruction. Some communicating canals deeply penetrate into the upper hypertrophic zone where they terminate, showing electron-dense cells at their end. Subcellular characteristics of these cells are hardly detectable and we suppose that they undergo cell death. Other canals pass down deeper into the lower hypertrophic zone. The upper segment of these canals is composed of capillaries, mesenchymal cells, and macrophage-like cells. Precursors of osteoblasts are adjacent to the canals. The lower segment of communicating canals is composed of bone matrix or osteoid, which contains type I collagen fibrils and cells having the typical subcellular features of osteoblas...Continue Reading

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Citations

Oct 13, 2009·Forensic Science International : Synergy·Olga RejtarováMichal Kuchar
Jul 8, 2008·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Michael J F BlumerHelga Fritsch
Jan 27, 2009·Journal of Anatomy·J R Mérida VelascoJ A Mérida Velasco
Jul 14, 2006·Anatomia, histologia, embryologia·M R B EslaminejadP E Yazdi
Feb 25, 2009·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Gregory J SchmidDavid M Ornitz
Jun 1, 2005·Medical Hypotheses·H BrandenburgA C Gittenberger-de Groot
Dec 21, 2016·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Simone GabnerPeter Böck
Oct 17, 2015·Journal of Anatomy·Ingunn Risnes HellingsKristin Olstad
Jul 13, 2007·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Michael J F BlumerHelga Fritsch
Feb 4, 2006·Microscopy Research and Technique·Michael W HessLukas A Huber
Mar 28, 2006·Journal of Pediatric Endocrinology & Metabolism : JPEM·Helen KaliraiJan-M Wit
Feb 19, 2021·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Michael J F Blumer
Jul 28, 2009·Developmental Biology·Julie GreenMatthew I Goldsmith

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