Cartilage T1ρ and T2 Relaxation Times in Patients With Mild-to-Moderate Radiographic Hip Osteoarthritis

Arthritis & Rheumatology
Cory WyattSharmila Majumdar

Abstract

To analyze region-specific T1ρ and T2 relaxation times of the hip joint cartilage in relation to presence or absence of radiographic hip osteoarthritis (OA) and presence or absence of magnetic resonance imaging (MRI)-detected cartilage defects. Weight-bearing radiographs and 3T MRI studies of the hip were obtained from 84 volunteers. Based on Kellgren/Lawrence (K/L) scoring of the radiographs, 54 subjects were classified as healthy controls (K/L grade ≤1) and 30 were classified as having mild or moderate radiographic hip OA (K/L grades 2 or 3, respectively). Two-dimensional fat-suppressed fast spin-echo MRI sequences were used for semiquantitative clinical scoring of cartilage defects, and a T1ρ/T2 sequence was used to quantitatively assess the cartilage matrix. The femoral and acetabular cartilage was then segmented into 8 regions and the mean T1ρ/T2 values were calculated. Differences in T1ρ and T2 relaxation times were compared between subjects with and those without radiographic hip OA, and those with and those without femoral or acetabular cartilage defects. Higher T1ρ and T2 relaxation times in the anterior superior and central regions of the acetabular cartilage were seen in individuals with radiographic hip OA and those...Continue Reading

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Citations

May 19, 2016·Journal of Magnetic Resonance Imaging : JMRI·Michael A SamaanSharmila Majumdar
Dec 27, 2016·Journal of Magnetic Resonance Imaging : JMRI·Thomas M LinkXiaojuan Li
May 23, 2017·Journal of Children's Orthopaedics·T HesperR Krauspe
Oct 19, 2017·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Deepak KumarSharmila Majumdar
Aug 2, 2017·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Michael A SamaanSharmila Majumdar
Oct 10, 2018·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Gaurav InamdarSharmila Majumdar
Mar 20, 2016·European Radiology·Lorenzo NardoRoland Krug
Mar 4, 2020·NMR in Biomedicine·Cory R WyattAlexander R Guimaraes
Apr 16, 2020·Journal of Magnetic Resonance Imaging : JMRI·Radhika TibrewalaSharmila Majumdar
Nov 4, 2016·Clinical Orthopaedics and Related Research·Tobias HesperYoung-Jo Kim
Oct 16, 2019·Journal of Magnetic Resonance Imaging : JMRI·Tzu-Chieh LiaoSharmila Majumdar
Jul 9, 2017·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Valentina PedoiaSharmila Majumdar
May 8, 2018·Journal of Magnetic Resonance Imaging : JMRI·Jasmine Rossi-deVriesSharmila Majumdar
Dec 29, 2020·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Radhika TibrewalaSharmila Majumdar
Feb 23, 2021·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Koren E RoachRichard B Souza

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