Cartilage thickening in early radiographic knee osteoarthritis: a within-person, between-knee comparison.

Arthritis Care & Research
Sebastian CotofanaOsteoarthritis Initiative Investigators Group

Abstract

To determine whether the presence of definite osteophytes (in the absence of joint space narrowing [JSN]) on radiographs is associated with (subregional) increases in cartilage thickness in a within-person, between-knee cross-sectional comparison of participants in the Osteoarthritis Initiative. Based on previous results, the external weight-bearing medial femoral condyle (ecMF) and external weight-bearing lateral femoral condyle (ecLF) subregions were selected as primary end points. Both knees of 61 Osteoarthritis Initiative participants (n = 4,796) displayed definite tibial or femoral marginal osteophytes and no JSN in 1 knee, and no signs of radiographic osteoarthritis (OA) in the contralateral knee; this was confirmed by an expert central reader. In these participants, cartilage thickness was measured in 16 femorotibial subregions of each knee, based on sagittal double-echo steady-state with water excitation magnetic resonance images. Location-specific joint space width from fixed-flexion radiographs was determined using dedicated software. Location-specific associations of osteophytes with cartilage thickness were evaluated using paired t-tests and mixed-effects models. Of the 61 participants, 48% had only medial osteophyt...Continue Reading

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Citations

Apr 15, 2014·Annals of the Rheumatic Diseases·Felix EcksteinUNKNOWN OAI investigators
Dec 20, 2013·Dento Maxillo Facial Radiology·G A P RendersV Everts
Jan 15, 2013·Rheumatic Diseases Clinics of North America·Ali GuermaziFrank W Roemer
Oct 10, 2013·Arthritis Care & Research·Sebastian CotofanaUNKNOWN Osteoarthritis Initiative Investigators
Mar 10, 2015·Lancet·S Glyn-JonesA J Carr
Jul 31, 2013·Osteoarthritis and Cartilage·T J MosherA Guermazi
Jul 16, 2015·Cartilage·Leif RydMarcy Zenobi-Wong
Jun 28, 2017·Journal of Athletic Training·Randy J SchmitzSandra J Shultz
Jul 12, 2012·Nature Reviews. Rheumatology·Felix EcksteinMichael C Nevitt
Jul 22, 2015·International Journal of Computer Assisted Radiology and Surgery·Marios PitikakisGianni Viano
Jun 5, 2015·Journal of Biomechanical Engineering·Michael E StenderVirginia L Ferguson
May 25, 2020·Journal of Magnetic Resonance Imaging : JMRI·James W MacKayFiona J Gilbert
May 10, 2017·Arthritis Research & Therapy·Nasimah MaricarTerence W O'Neill
Apr 17, 2020·BMC Musculoskeletal Disorders·Kade L PatersonRana S Hinman

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