PMID: 15346084Sep 4, 2004Paper

Cartilage tolerates single impact loads of as much as half the joint fracture threshold

Clinical Orthopaedics and Related Research
Joseph BorrelliMatthew J Silva

Abstract

We hypothesized that one mechanical insult could affect cellular proliferation, matrix turnover, and the structural integrity of cartilage, and that these effects would be dose dependent and time dependent. One impact load of low impact (14.4 MPa +/- 2.1 MPa), medium impact (22.8 MPa +/- 5.8 MPa), or high impact (55.5 MPa +/- 12.6 MPa) was administered to the posterior aspect of the medial femoral condyle of New Zealand White rabbits using a previously validated pendulum device. Animals were euthanized at 2, 6, and 12 weeks after impact, and the impacted and sham (contralateral limb) cartilage were harvested. Each specimen was assessed by light microscopy and by immunohistochemical methods. Although impacted specimens had greater loss of proteoglycan staining than sham cartilage, these changes were neither dose dependent nor time dependent. No structural damage, enzymatic proteoglycan or collagen breakdown, or cellular proliferation was identified in the different impact groups. Articular cartilage is a resilient tissue, particularly in situ, and can tolerate single impact loads of as much as 45% of the joint fracture threshold without considerable disruption or degradation.

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Citations

Jan 24, 2007·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·C C Scott, K A Athanasiou
Jul 8, 2008·Journal of Biomechanical Engineering·Roman M Natoli, Kyriacos A Athanasiou
Mar 13, 2010·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Joseph BorrelliMatthew J Silva
Aug 26, 2010·Journal of Orthopaedic Trauma·David M BearConstance R Chu
Feb 22, 2011·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Jonathon D BackusSteven A Olson
Apr 27, 2011·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Donald D AndersonJoseph A Buckwalter
Apr 18, 2020·Annals of Biomedical Engineering·Ervin NippolainenIsaac O Afara
Oct 17, 2008·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Joseph BorrelliLinda J Sandell
Jun 18, 2016·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Carina L BlakerChristopher B Little
May 6, 2015·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Steven A OlsonFarshid Guilak
Oct 21, 2016·Journal of Biomechanical Engineering·Corinne R HenakLawrence J Bonassar
Jun 4, 2010·Computer Methods in Biomechanics and Biomedical Engineering·N H YangA Vaziri

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