PMID: 29848829Jun 1, 2018Paper

Cartilage/chondrocyte research and osteoarthritis. Intra-articular injection of mesenchymal stem cells for the treatment of osteoarthritis

Clinical calcium
Atsuhiko Hikita

Abstract

Mesenchymal stem cells(MSCs)are reported to have not only multipotency, but also anti-inflammatory and tissue repairing effects. Assays using animal models for osteoarthritis show that MSCs suppress the degeneration of cartilage. Based on these data, clinical researches and clinical trials have been performed for the treatment of osteoarthritis using MSCs. Results of these trials show the safety of the treatment, improvement of the symptoms, and findings indicating the cartilage repair. For the industrialization of the treatment using MSCs, application of allogenic cells has many advantages, while issues such as the immune reaction must be overcome.

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