Carvacrol promotes neuroprotection in the mouse hemiparkinsonian model

Neuroscience
L M DatiLuiz R Britto

Abstract

Carvacrol is a monoterpene that has been linked to neuroprotection in several animal models of neurodegeneration, including ischemia, epilepsy and traumatic neuronal injury. In this study, we investigated the effects of carvacrol (i.p.) upon the neurodegeneration induced by 6-hydroxy-dopamine unilateral intrastriatal injections in mice. We have also used the cylinder test to assess the behavioral effects of carvacrol in that model of Parkinson's disease, and immunoblots to evaluate the levels of caspase-3 and TRPM7, one of major targets of carvacrol. Behavioral testing revealed that carvacrol largely reduced the asymmetrical use of the forelimbs induced by unilateral 6-hydroxy-dopamine. Carvacrol dramatically reduced the loss of tyrosine hydroxylase immunostaining both in the substantia nigra and in the striatum that are typical of the model. Immunoblots for tyrosine hydroxylase confirmed this effect. Caspase-3 levels were very high after toxin injections, but carvacrol appeared to reduce them to control levels. Finally, TRPM7, observed by immunoblots, increased after 6-hydroxy-dopamine, suggesting the involvement of this cation channel in the ensuing neurodegenerative process. The present data suggest that carvacrol promotes a...Continue Reading

Citations

Sep 6, 2018·Current Neuropharmacology·Yulia A SidorovaNariman F Salakhutdinov
Jan 16, 2020·Naunyn-Schmiedeberg's Archives of Pharmacology·Jalles Dantas de LucenaGlauce Socorro de Barros Viana
Jun 27, 2019·Basic & Clinical Pharmacology & Toxicology·Milad AshrafizadehShima Tavakol
Nov 16, 2019·Naunyn-Schmiedeberg's Archives of Pharmacology·Azadeh Shahrokhi RaeiniFatemeh Zare Mehrjerdi
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Dec 15, 2021·The European Journal of Neuroscience·Kubra Celik TopkaraSerif Demir

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