PMID: 1350479Jan 1, 1992Paper

Carvedilol and the kidney

The Clinical Investigator
A G Dupont

Abstract

Antihypertensive drugs have differing effects on renal hemodynamics, tubular function, plasma electrolytes, and hormonal responses. Nonselective beta-blockers without intrinsic sympathomimetic activities, such as propranolol, have been reported to reduce renal blood flow and to cause a modest decrease in glomerular filtration rate. Carvedilol is a new multiple action agent displaying nonselective beta-blockade without intrinsic sympathicomimetic activity, alpha 1-adrenoceptor blockade (probably responsible for its vasodilator activity), and possibly also calcium antagonist properties. The presence of these different pharmacodynamic properties results in a different effect on the kidney as compared with, e.g., propranolol. In the dog, intrarenal infusion of carvedilol resulted in a renal vasodilator response with preservation of renal blood flow and without inducing sodium retention; in contrast, propranolol induced a renal vasoconstrictor response and sodium retention in this model. A renal vasodilator response to carvedilol was also reported in spontaneously hypertensive rats (SHR) and in DOCA-salt SHR. In contrast to labetalol, i.v. infusion of hypotensive doses of carvedilol in conscious SHR did not cause sodium retention. C...Continue Reading

Citations

Nov 26, 2002·Biochemical Pharmacology·Chun-Peng LiuChung-Ren Jan
Jun 5, 2012·Vascular Health and Risk Management·Gastone Leonetti, Colin G Egan
Jan 3, 2015·International Journal of Cardiology·Gabriel CaoJosé Milei
Oct 6, 2006·Kidney International·George BakrisE Ritz
Sep 18, 2007·Seminars in Nephrology·Peter D Hart, George Bakris
May 1, 2015·Canadian Journal of Physiology and Pharmacology·Hala Salah Abdel Kawy

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