PMID: 15374060Sep 18, 2004Paper

Carvedilol in elderly patients with chronic heart failure, a 12 weeks randomized, placebo controlled open trial

Archives of Gerontology and Geriatrics
R Leonetti LupariniV Marigliano

Abstract

The encouraging results of recent multicenter clinical trials conducted in the US on the effect of carvedilol therapy in patients with chronic heart failure, prompted us to verify its tolerability in a group of elderly patients. For the open, randomized, placebo-controlled study, we selected 40 patients (28 men and 12 women, mean age 76.8+/-5.9 years) with mild, moderate or severe chronic heart failure. Exclusion criteria included dementia, chronic hepatitis, renal failure, severe vascular disease and respiratory failure. All patients were receiving treatment with digitalis, furosemide and ACE inhibitors. The study lasted 12 weeks. During the first week, all subjects received oral placebo or carvedilol, at a dose of 6.25 mg twice daily. The twice daily dose was then increased to 12.5 mg during weeks 2-4 and to 25 mg from weeks 5-12. At 0, after the 2 weeks of run-in, 4 and 12 weeks patients underwent assessment of systolic and diastolic blood pressure, heart rate, left ventricular ejection fraction, cognitive status and functional ability. Our findings indicate that elderly patients with congestive heart failure tolerate carvedilol therapy well. Carvedilol slightly improves heart function without altering functional or cognitiv...Continue Reading

References

Oct 1, 1975·British Heart Journal·F WaagsteinI Wallentin
Jan 1, 1970·The Gerontologist·S KatzR C Grotz
May 1, 1995·Journal of the American College of Cardiology·S L OlsenM R Bristow

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Citations

Nov 1, 2005·Future Cardiology·Robin Ap Weir, Henry J Dargie
Aug 6, 2013·Drugs & Aging·Kannayiram AlagiakrishnanWilbert S Aronow
Jun 29, 2018·The Cochrane Database of Systematic Reviews·Nicole MartinR Thomas Lumbers
May 23, 2021·The Cochrane Database of Systematic Reviews·Nicole MartinR Thomas Lumbers

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