Carvedilol protects bone marrow stem cells against hydrogen peroxide-induced cell death via PI3K-AKT pathway

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Meihui ChenDingkun Lin

Abstract

Carvedilol, a nonselective β-adrenergic receptor blocker, has been reported to exert potent anti-oxidative activities. In the present study, we aimed to investigate the effects of carvedilol against hydrogen peroxide (H2O2)-induced bone marrow-derived mesenchymal stem cells (BMSCs) death, which imitate the microenvironment surrounding transplanted cells in the injured spinal cord in vitro. Carvedilol significantly reduced H2O2-induced reactive oxygen species production, apoptosis and subsequent cell death. LY294002, the PI3K inhibitor, blocked the protective effects and up-regulation of Akt phosphorylation of carvedilol. Together, our results showed that carvedilol protects H2O2-induced BMSCs cell death partly through PI3K-Akt pathway, suggesting carvedilol could be used in combination with BMSCs for the treatment of spinal cord injury by improving the cell survival and oxidative stress microenvironments.

References

Apr 2, 1999·Science·M F PittengerD R Marshak
Jun 14, 2006·Transplantation·Seiichiro InoueMarc H Dahlke
Mar 24, 2007·Cardiovascular & Hematological Disorders Drug Targets·R S CarreiraL A Providência
Jul 6, 2007·Journal of the Neurological Sciences·Marco BacigaluppiDirk M Hermann
Sep 27, 2007·PloS One·Biju ParekkadanMartin L Yarmush
Mar 21, 2009·Transplantation·Meindert J CropMartin J Hoogduijn
Feb 10, 2012·Molecular Neurodegeneration·Ping K Yip, Andrea Malaspina
Mar 21, 2012·Pediatric Research·Jignesh DalalJos Domen
Oct 4, 2014·Clinical Epidemiology·Anoushka SinghMichael G Fehlings

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Citations

Jul 30, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·ZhenQiu ChenMei Hui Chen
Oct 21, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·QiuShi WeiMei Hui Chen
Nov 11, 2017·Journal of Cellular Biochemistry·Lin GaoZhiqiang Zhang
Oct 22, 2020·Acta Biochimica Et Biophysica Sinica·Huaqiang TaoDechun Geng
Sep 4, 2018·JACC. Basic to Translational Science·Misun Park, Susan F Steinberg
Jun 6, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Han-Bing SongXue-Yan Jiang

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