Carvedilol versus verapamil in chronic stable angina: a multicentre trial

European Journal of Clinical Pharmacology
U Hauf-ZachariouE Pfarr

Abstract

In a multicentre, double-blind, parallel group study, the anti-anginal and the anti-ischaemic efficacy of 12 weeks of therapy with the vasodilating beta-adrenoceptor-blocker carvedilol 25 mg b.i.d. was compared with verapamil 120 mg t.i.d. During a 2-week placebo run-in period, patients were required to have two treadmill exercise tests (modified Bruce Protocol) differing by not more than 15% with regard to total exercise time (TET). Of 313 patients enrolled, 248 were randomized and 212 completed the study according to the protocol. The primary variable TET was analysed using the Cox Proportional Hazards Model to take into account censored values due to the patient stopping the exercise test for reasons other than angina. Forty-three per cent of patients allocated to carvedilol and 36% to verapamil did not stop with angina at the final visit. There was no difference in the TET between the groups, the risk ratio being 1.14 in favour of carvedilol (90% CI 0.85-1.52). TET increased from 378 s at baseline to 436 s at the final visit in the carvedilol group and from 386 to 438 s in the verapamil group. Results for time to angina and time to 1 mm ST-segment depression were similar. Compared to verapamil, carvedilol significantly redu...Continue Reading

Citations

Nov 21, 2001·Current Opinion in Pharmacology·A E DenktasR S Schwartz
Sep 1, 2001·Dimensions of Critical Care Nursing : DCCN·A Barkman, C Pooler
Jul 21, 2012·Pharmacology·Nobumitsu HaniokaShizuo Narimatsu
Sep 21, 2013·Expert Opinion on Pharmacotherapy·Ashish K GuptaCarl J Pepine
Jan 15, 2014·Expert Review of Cardiovascular Therapy·Raj Parikh, Philip J Kadowitz
May 10, 2000·The American Journal of Cardiology·M BrunnerM Zehender
Nov 26, 1999·Biochemical Pharmacology·O JonssonK Grankvist
Jan 26, 2017·Drugs·Talla A RousanUdho Thadani
May 20, 2015·JAAPA : Official Journal of the American Academy of Physician Assistants·Deepali Dixit, Katarzyna Kimborowicz
Sep 1, 2011·Nature Reviews. Cardiology·Bernard R Chaitman, Abhay A Laddu
Jan 28, 2004·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Akiko OhnoJun-ichi Sawada
Aug 3, 2001·Cardiovascular Drug Reviews·J ChengI Kodama
Jul 11, 2012·European Journal of Preventive Cardiology·De Fen ShuGuan Jian Liu
Sep 19, 2002·Vojnosanitetski pregled. Military-medical and pharmaceutical review·Dragan TavciovskiRadomir Matunović

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