Feb 25, 2014

Cas adaptor proteins organize the retinal ganglion cell layer downstream of integrin signaling

Neuron
Martin M RiccomagnoAlex L Kolodkin

Abstract

Stratification of retinal neuronal cell bodies and lamination of their processes provide a scaffold upon which neural circuits can be built. However, the molecular mechanisms that direct retinal ganglion cells (RGCs) to resolve into a single-cell retinal ganglion cell layer (GCL) are not well understood. The extracellular matrix protein laminin conveys spatial information that instructs the migration, process outgrowth, and reorganization of GCL cells. Here, we show that the β1-Integrin laminin receptor is required for RGC positioning and reorganization into a single-cell GCL layer. β1-Integrin signaling within migrating GCL cells requires Cas signaling-adaptor proteins, and in the absence of β1-Integrin or Cas function retinal neurons form ectopic cell clusters beyond the inner-limiting membrane (ILM), phenocopying laminin mutants. These data reveal an essential role for Cas adaptor proteins in β1-Integrin-mediated signaling events critical for the formation of the single-cell GCL in the mammalian retina.

  • References26
  • Citations10

Citations

Mentioned in this Paper

Vertebrates
Embryo
RPSA gene
Biochemical Pathway
Presynaptic Terminals
Anatomical Layer
Immunohistochemistry
Entire Retina
Projections and Predictions
Uterus

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