CASC2/miR-24/miR-221 modulates the TRAIL resistance of hepatocellular carcinoma cell through caspase-8/caspase-3

Cell Death & Disease
Xiaoxin JinJichun Sun

Abstract

Hepatocellular carcinoma is one of the most common solid tumors in the digestive system. The prognosis of patients with hepatocellular carcinoma is still poor due to the acquisition of multi-drug resistance. TNF Related Apoptosis Inducing Ligand (TRAIL), an attractive anticancer agent, exerts its effect of selectively inducing apoptosis in tumor cells through death receptors and the formation of the downstream death-inducing signaling complex, which activates apical caspases 3/8 and leads to apoptosis. However, hepatocellular carcinoma cells are resistant to TRAIL. Non-coding RNAs, including long non-coding RNAs (lncRNAs) and miRNAs have been regarded as major regulators of normal development and diseases, including cancers. Moreover, lncRNAs and miRNAs have been reported to be associated with multi-drug resistance. In the present study, we investigated the mechanism by which TRAIL resistance of hepatocellular carcinoma is affected from the view of non-coding RNA regulation. We selected and validated candidate miRNAs, miR-24 and miR-221, that regulated caspase 3/8 expression through direct targeting, and thereby affecting TRAIL-induced tumor cell apoptosis TRAIL resistance of hepatocellular carcinoma. In addition, we revealed t...Continue Reading

References

Jul 20, 1999·The Journal of Clinical Investigation·A AshkenaziR H Schwall
Mar 23, 2000·Journal of Hepatology·H Bismuth, P E Majno
Oct 24, 2002·Journal of Clinical Gastroenterology·Massimo Di MaioBruno Daniele
Mar 7, 2003·Molecular Cell·Kelly M BoatrightGuy S Salvesen
Mar 26, 2003·Cell Death and Differentiation·H N LeBlanc, A Ashkenazi
Oct 28, 2004·Gastroenterology·Brian I Carr
Apr 4, 2007·The International Journal of Biochemistry & Cell Biology·Christina FalschlehnerHenning Walczak
Feb 26, 2009·Cell·Chris P PontingWolf Reik
Apr 8, 2010·Expert Review of Molecular Diagnostics·Manuela FerracinMassimo Negrini
Apr 21, 2010·Annals of Surgical Oncology·Andrew X Zhu
Jun 15, 2010·Current Opinion in Pharmacology·Helen M HeneghanMichael J Kerin
Dec 3, 2010·The Journal of Pathology·Thalia A FaraziThomas Tuschl
Sep 29, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Nataliya RazumilavaJustin L Mott
Apr 10, 2013·Journal of Cancer Research and Clinical Oncology·Tao SongBaofa Hong
Jul 6, 2013·Cell Death & Disease·K WangP-F Li
Jul 10, 2013·Current Drug Targets·Liu HongDaiming Fan
Jan 17, 2014·Nature·Yvonne TayPier Paolo Pandolfi
May 13, 2014·Journal of Cancer Research and Clinical Oncology·Shuigen ZhouZhengyu Zhang
Mar 10, 2015·FEBS Letters·Nianli LiuHaizhen Zhu
Sep 8, 2015·Pharmacology & Therapeutics·Gustavo P Amarante-Mendes, Thomas S Griffith
Nov 27, 2015·World Journal of Hepatology·Lisa P WallerNikolaos Pyrsopoulos
Jan 23, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Xuezhi HeRenhua Guo
Feb 28, 2017·International Journal of Cancer. Journal International Du Cancer·Duc-Hiep BachSang Kook Lee
May 13, 2017·Archives of Biochemistry and Biophysics·Yeqian FengLili Sun
Jun 18, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yuanyuan GanXiming Xu
Sep 3, 2017·Journal of Cellular Biochemistry·Yaqun YuWeijia Liao

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Citations

Jul 29, 2020·Cells·Jovana MarkovicAsha Balakrishnan
Jul 19, 2020·Cell Biochemistry and Biophysics·Mariana M MonteiroMarinilce F Santos
Dec 15, 2020·European Journal of Pharmacology·Milad AshrafizadehMasoud Najafi
Jan 9, 2021·Cell Death & Disease·Sergey ParfenyevNiсkolai A Barlev
Oct 31, 2020·Frontiers in Oncology·Sumei WangWanyin Wu
Sep 27, 2020·Pathology, Research and Practice·Hui ZhangYanli Li
Jul 3, 2021·Cancers·Ezgi Ozyerli-Goknar, Tugba Bagci-Onder

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Methods Mentioned

BETA
PCR
chip
RIP
transfection

Software Mentioned

miRCode
SPSS
miRWalk
RNA22
Targetscan
Starbase

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