PMID: 8939454Nov 1, 1996Paper

Cascade of gene expression induced by Ca2+ signals in neurons

Neurochemistry International
M Tsuda

Abstract

To understand the cellular processes involved in learning and memory, the cellular responses of neurons to calcium (Ca2+) signals, which can be evoked via synaptic activity, should be examined. A series of investigations in primary cultures of neurons revealed that the regulation of brain-derived neurotrophic factor (BDNF) mRNA expression is mediated by almost the same Ca2+ signaling pathways as that of c-fos mRNA expression. Such early co-activation of both genes in response to Ca2+ signals further suggests that sets of calcium-responsive genes (CaRGs) are concurrently activated by Ca2+ signals. The products encoded by CaRGs should then evoke a variety of physiological responses in neurons with the expression of another set of genes, the products of which are directly involved in the outcomes of neuronal functions. Thus, a cascade of gene expression can be induced by Ca2+ signals evoked via synaptic activity. It is of particular interest to identify the CaRGs and investigate the regulational mechanisms of their expression. A cellular approach using primary cultures of neurons would therefore lead to a better understanding of the intracellular processes involved in learning and memory.

References

Oct 11, 1992·Nucleic Acids Research·J WelshM McClelland
Oct 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·E CastrénD Lindholm
Apr 18, 1995·Brain Research. Developmental Brain Research·T KuboH Hatanaka
Oct 27, 1995·Science·H Thoenen
Dec 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·S R D'MelloP Calissano
Oct 1, 1992·The European Journal of Neuroscience·Patrik ErnforsHåkan Persson

❮ Previous
Next ❯

Citations

Oct 3, 2002·Biochemical and Biophysical Research Communications·S MukobataF Tashiro
Jan 26, 2006·European Journal of Human Genetics : EJHG·Nicola FilippiniMassimo Gennarelli

❮ Previous
Next ❯

Related Concepts

Related Feeds

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.