Case-based reasoning using electronic health records efficiently identifies eligible patients for clinical trials

Journal of the American Medical Informatics Association : JAMIA
Riccardo Miotto, Chunhua Weng

Abstract

To develop a cost-effective, case-based reasoning framework for clinical research eligibility screening by only reusing the electronic health records (EHRs) of minimal enrolled participants to represent the target patient for each trial under consideration. The EHR data--specifically diagnosis, medications, laboratory results, and clinical notes--of known clinical trial participants were aggregated to profile the "target patient" for a trial, which was used to discover new eligible patients for that trial. The EHR data of unseen patients were matched to this "target patient" to determine their relevance to the trial; the higher the relevance, the more likely the patient was eligible. Relevance scores were a weighted linear combination of cosine similarities computed over individual EHR data types. For evaluation, we identified 262 participants of 13 diversified clinical trials conducted at Columbia University as our gold standard. We ran a 2-fold cross validation with half of the participants used for training and the other half used for testing along with other 30 000 patients selected at random from our clinical database. We performed binary classification and ranking experiments. The overall area under the ROC curve for clas...Continue Reading

References

Jan 1, 1994·Journal of the American Medical Informatics Association : JAMIA·J J CiminoS B Johnson
Sep 1, 1996·Journal of the American Medical Informatics Association : JAMIA·S B Johnson
May 30, 1998·Journal of Medical Systems·C PapaconstantinouS Mahadevan
Jun 1, 2000·Journal of the American Medical Informatics Association : JAMIA·J J Cimino
Jul 19, 2002·Journal of Biomedical Informatics·W W ChapmanB G Buchanan
Nov 21, 2008·Journal of Evaluation in Clinical Practice·Claude DussartSophie Dussart
Sep 1, 2009·Journal of the American Medical Informatics Association : JAMIA·Samir R ThadaniDavid Wajngurt
Dec 26, 2009·Journal of Biomedical Informatics·Chunhua WengRachel Richesson
Sep 21, 2010·Journal of Biomedical Informatics·Samson W TuIda Sim
Apr 5, 2011·International Journal of Medical Informatics·Marc CuggiaDavid Glasspool
Jun 1, 2011·Drug Discovery Today·Lixia YaoPankaj Agarwal
Aug 3, 2011·Journal of the American Medical Informatics Association : JAMIA·Chunhua WengStephen B Johnson
Dec 23, 2011·BMC Bioinformatics·Halil BisginWeida Tong
May 3, 2012·Nature Reviews. Genetics·Peter B JensenSøren Brunak
Sep 8, 2012·Journal of the American Medical Informatics Association : JAMIA·George Hripcsak, David J Albers
Jul 4, 2013·Journal of Biomedical Informatics·Nicole G WeiskopfChunhua Weng
Aug 7, 2013·Journal of Biomedical Informatics·Riccardo MiottoChunhua Weng
Sep 17, 2013·Journal of Biomedical Informatics·Riccardo Miotto, Chunhua Weng

❮ Previous
Next ❯

Citations

Mar 27, 2016·Journal of the American Medical Informatics Association : JAMIA·Michael H EubankPeter D Stetson
Aug 9, 2016·Journal of the American Medical Informatics Association : JAMIA·Kirk RobertsPatricia Flatley Brennan
Apr 14, 2016·Journal of Biomedical Informatics·Julia Hoxha, Chunhua Weng
Mar 5, 2016·Methods of Information in Medicine·Tianyong HaoChunhua Weng
Apr 27, 2018·Pharmacogenomics·Alexandr A KalininBrian D Athey
Sep 29, 2019·Clinical Pharmacology and Therapeutics·Brett K Beaulieu-JonesKun-Hsing Yu
May 10, 2017·Briefings in Bioinformatics·Riccardo MiottoJoel T Dudley
Apr 20, 2018·BMC Bioinformatics·Huaixiao TouBo Zhang
Jun 15, 2019·Journal of the American Medical Informatics Association : JAMIA·V G Vinod VydiswaranNalingna Yuan
Sep 19, 2019·Journal of the American Medical Informatics Association : JAMIA·Amir Alishahi TabrizJennifer Elston Lafata
Mar 25, 2017·Journal of the American Medical Informatics Association : JAMIA·Kevin Zhang, Dina Demner-Fushman
Aug 5, 2017·Journal of Healthcare Informatics Research·Shreya ChakrabartiChunhua Weng
Feb 28, 2019·BMC Medical Research Methodology·Laura M BeskowCatherine M Hammack
Apr 8, 2020·Journal of Clinical and Translational Science·Teresa TaftJulio C Facelli
Oct 23, 2019·BMC Medical Informatics and Decision Making·Christian KarmenMatthias Ganzinger
Nov 18, 2018·Journal of the American Medical Informatics Association : JAMIA·Emily PfaffDarren A DeWalt
Sep 26, 2020·Artificial Intelligence in Medicine·Suresh PokharelYu Li
Mar 23, 2021·Computers & Industrial Engineering·Houssein DhayneYehia Taher
May 6, 2021·Journal of Clinical and Translational Science·Laura M BeskowCatherine M Hammack-Aviran
Jul 31, 2021·Frontiers in Neurology·Christina M LinebackShyam Prabhakaran
Oct 14, 2020·Journal of Biomedical Informatics·Mario QuindeAléchia van Wyk

❮ Previous
Next ❯

Software Mentioned

RxNorm
NegEx
comb
MED
UMLS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Medical Decision Making : an International Journal of the Society for Medical Decision Making
N A Desbiens
Medicina clínica
G Garrido Cantarero, R Madero Jarabo
© 2021 Meta ULC. All rights reserved