Case-based surveillance enhanced with measles virus detection/genotyping is essential to maintain measles elimination in Aichi Prefecture, Japan

Vaccine
Hiroko MinagawaTeruo Yamashita

Abstract

Japan was verified as having achieved measles elimination by the Measles Regional Verification Commission in the Western Pacific Region in March 2015. Verification of measles elimination implies the absence of continuous endemic transmission. After the last epidemic in 2007 with an estimated 18,000 cases, Japan introduced nationwide case-based measles surveillance in January 2008. Laboratory diagnosis for all suspected measles cases is essentially required by law, and virus detection tests are mostly performed by municipal public health institutes. Despite relatively high vaccination coverage and vigorous response to every case by the local health center staff, outbreak of measles is repeatedly observed in Aichi Prefecture, Japan. Measles virus N and H gene detection by nested double RT-PCR was performed with all specimens collected from suspected cases and transferred to our institute. Genotyping and further molecular epidemiological analyses were performed with the direct nucleotide sequence data of appropriate PCR products. Between 2010 and 2014, specimens from 389 patients suspected for measles were tested in our institute. Genotypes D9, D8, H1 and B3 were detected. Further molecular epidemiological analyses were helpful to...Continue Reading

References

Jun 17, 2011·The Journal of Infectious Diseases·Paul A RotaDavid Featherstone
May 30, 2012·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Shalini DesaiRosamund Lewis
Sep 22, 2012·Japanese Journal of Infectious Diseases·Hiroshi Yoshikura
Aug 1, 2014·Western Pacific Surveillance and Response Journal : WPSAR·Takuri TakahashiKazunori Oishi
Dec 3, 2014·Vaccine·David N DurrheimPeter M Strebel

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Citations

Jul 25, 2019·Frontiers in Microbiology·Fumio SekiUNKNOWN Technical Support Team for Measles Control in Japan

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