Case-control analyses of the impact of pharmacotherapy on prospectively observed suicide attempts and completed suicides in bipolar disorder: findings from STEP-BD

The Journal of Clinical Psychiatry
Lauren MarangellMichael E Thase

Abstract

Given high rates of suicide and suicide attempts in bipolar disorder and the data suggesting a suicide-protective effect of lithium, we evaluated the impact of pharmacotherapy on prospectively observed suicides and suicide attempts in subjects in the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD). The STEP-BD study enrolled 4360 participants with DSM-IV bipolar disorder diagnoses from September 1998 through November 2004. There were 270 suicide events in STEP-BD (8 completed suicides, 262 attempts). These occurred in 182 of STEP-BD participants (cases). Inclusion criteria required cases to be white or Caucasian, have at least 1 postbaseline visit, and have prescription information within 30 days of the suicide event. This reduced the available cohort to 106 cases. Matching included age, gender, history of previous suicide attempt, and a propensity score that considered bipolar subtype, marital status, age at onset, and history of psychosis, resulting in 93 matched pairs. A secondary analysis added mood state status within 30 days of the suicide event to the propensity score (N = 54 pairs). The association of drug prescriptions with suicide attempts/completions was assessed using a conditional logistic r...Continue Reading

Citations

Jul 4, 2012·Archives of General Psychiatry·Tina R GoldsteinBoris Birmaher
Jul 4, 2012·Journal of Affective Disorders·Ralph J KoekJim Mintz
Feb 12, 2010·Annals of General Psychiatry·Christos ChristodoulouLefteris Lykouras
Mar 24, 2017·International Journal of Bipolar Disorders·Ayal SchafferAnthony J Levitt
Apr 7, 2010·CNS Spectrums·Michael H Allen
Mar 13, 2012·Acta Psychiatrica Scandinavica·U WernekeB Stegmayr
Jun 13, 2013·Bipolar Disorders·Maurizio PompiliPaolo Girardi
Aug 19, 2014·Expert Review of Neurotherapeutics·Genevieve Curran, Arun Ravindran
Jul 23, 2013·Bipolar Disorders·Boghos I Yerevanian, Young Mee Choi
May 29, 2016·Bipolar Disorders·Elizabeth D BallardCarlos A Zarate
Aug 21, 2016·Current Psychiatry Reports·Leonardo Tondo, Ross J Baldessarini
May 6, 2010·CNS Drugs·Jonathan C PfeiferMelissa P DelBello
Sep 5, 2014·Harvard Review of Psychiatry·Othman Mohammad, David N Osser
Nov 11, 2011·CNS Neuroscience & Therapeutics·Zoltan Rihmer, Xenia Gonda
Dec 24, 2008·Expert Review of Neurotherapeutics·Maurizio PompiliRoberto Tatarelli
Jan 7, 2020·International Journal of Bipolar Disorders·Ross J BaldessariniLeonardo Tondo

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bipolar Disorder

Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.