Case-control association study of Disrupted-in-Schizophrenia-1 (DISC1) gene and schizophrenia in the Chinese population

Journal of Psychiatric Research
Qing-Ying ChenLin He

Abstract

Disrupted-in-Schizophrenia-1 (DISC1) has first been identified as a candidate gene for schizophrenia through study of a Scottish family with a balanced (1; 11) (q42.1; q14.3) translocation. Lots of linkage and association studies supported DISC1 as a risk factor for schizophrenia. In this study, we genotyped three SNPs in DISC1 using a set of Han Chinese samples of 560 schizophrenics and 576 controls. No positive association was detected in the whole samples but analysis of allele frequencies in female samples showed weak association between SNP rs2295959 and the disease (chi(2)=6.188, P=0.0135, OR=0.728, 95% CI=0.567-0.935). Our results provide further evidence for sex difference for the effect of the gene on the aetiology of schizophrenia. Our findings also would encourage further studies, particularly family-based association studies with larger samples, to analyze the association between DISC1 and schizophrenia.

References

Dec 15, 1993·JAMA : the Journal of the American Medical Association·W B DobynsD H Ledbetter
May 18, 2000·Human Molecular Genetics·J K MillarD J Porteous
Apr 17, 2001·American Journal of Medical Genetics·T A GreenwoodJ R Kelsoe
Jul 27, 2001·Human Molecular Genetics·J EkelundL Peltonen
Feb 13, 2002·American Journal of Medical Genetics·Michel MaziadeChantal Mérette
Apr 27, 2002·Science·Douglas F LevinsonMarilyn Walters
May 25, 2002·Human Molecular Genetics·Kodavali V ChowdariVishwajit L Nimgaonkar
Dec 24, 2002·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Claudine LaurentJacques Mallet
Dec 31, 2002·Proceedings of the National Academy of Sciences of the United States of America·Yuji OzekiAkira Sawa
May 13, 2003·Molecular Psychiatry·H-G HwuS F-C Lee
May 29, 2003·Human Heredity·Linda M BrzustowiczAnne S Bassett
Aug 14, 2003·Genetic Epidemiology·Frank Dudbridge
Nov 19, 2003·Biochemical and Biophysical Research Communications·J Kirsty MillarDavid J Porteous
Jun 9, 2004·Nature Genetics·Jun MukaiJoseph A Gogos
Jun 16, 2004·Molecular Psychiatry·J EkelundL Peltonen
Jan 20, 2005·Proceedings of the National Academy of Sciences of the United States of America·Naoya SawamuraAkira Sawa
Feb 25, 2005·Proceedings of the National Academy of Sciences of the United States of America·Mirian A F HayashiAntonio C M Camargo
Jun 9, 2005·Proceedings of the National Academy of Sciences of the United States of America·Joseph H CallicottDaniel R Weinberger
Jul 26, 2005·Schizophrenia Research·Xuan ZhangTsukasa Sasaki

❮ Previous
Next ❯

Citations

Feb 4, 2009·Archives of General Psychiatry·Liisa TomppoJesper Ekelund
May 14, 2008·Current Psychiatry Reports·Walter J MuirDouglas H R Blackwood
Oct 4, 2007·Molecular Psychiatry·J E ChubbJ K Millar
Oct 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Kenji NakataJoel E Kleinman
May 16, 2006·Schizophrenia Bulletin·William HennahDavid Porteous
Aug 16, 2012·Genes, Brain, and Behavior·R DebonoT R Merriman
Sep 28, 2010·Annual Review of Pharmacology and Toxicology·Hisham M Ibrahim, Carol A Tamminga
Nov 26, 2009·Neuromolecular Medicine·Shusuke NumataTetsuro Ohmori
Jul 10, 2009·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Yu-Li LiuHai-Gwo Hwu
Dec 7, 2007·Molecular and Cellular Neurosciences·Qi WangNicholas J Brandon
Feb 5, 2009·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Ayyappan AnithaNorio Mori
Feb 14, 2008·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·J B G HayesmooreM C O'Donovan
Jul 21, 2012·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Anna K KählerIngrid Agartz
Jan 1, 2008·Biochemical and Biophysical Research Communications·Wenjia SongSteve S Sommer
Jun 19, 2007·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Stephan ZüchnerJean C Beckham
Feb 12, 2015·Psychiatry Investigation·A Talib NorlelawatiWan Taib Wan Rohani
May 17, 2017·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Louis-David LordMorten L Kringelbach
May 21, 2014·Psychiatry Investigation·Javier Vázquez-BourgonBenedicto Crespo-Facorro
Jan 18, 2008·Journal of Medicinal Chemistry·Michael J MarinoMichael Williams

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.