Case-Control Pilot Study of Soft Contact Lens Wearers With Corneal Infiltrative Events and Healthy Controls

Investigative Ophthalmology & Visual Science
Kathryn RichdaleG Lynn Mitchell

Abstract

The purpose of this study was to assess risk factors associated with soft contact lens (SCL)-related corneal infiltrative events (CIEs). This was a single-visit, case-control study conducted at five academic centers in North America. Cases were defined as current SCL wearers with a symptomatic CIE. For each case, three age- and sex-matched controls were enrolled. Subjects completed the Contact Lens Risk Survey (CLRS), a standardized scripted medical interview, supplied a recent health history, and underwent an ocular examination. Microbial culturing of the ocular surface, SCL, and lens storage case was conducted for all cases and one of the three matched controls. Univariate and multivariate logistic regression modeling were used to assess the risk of developing a CIE. Thirty cases and 90 controls 13 to 31 years of age completed the study. Corneal infiltrative event diagnosis included contact lens-associated red eye, infiltrative keratitis, and contact lens peripheral ulcer. Subjects with symptomatic CIEs were more likely to harbor substantial levels of gram-negative bioburden on the ocular surface and contact lens. Significant risk factors for developing a CIE were overnight wear of SCLs, use of multipurpose solution, rinsing ...Continue Reading

Citations

Aug 17, 2016·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·Robin L ChalmersAaron Zimmerman
Jan 27, 2018·Eye & Contact Lens·Chris H L LimJodhbir S Mehta
Dec 27, 2018·Eye & Contact Lens·Jason J NicholsLoretta Szczotka-Flynn
Mar 1, 2019·Investigative Ophthalmology & Visual Science·Kate L GiffordPadmaja Sankaridurg
Feb 23, 2019·Cornea·Memoona ArshadFiona Stapleton
Nov 15, 2019·Cornea·Noor Haziq SalimanCarole Maldonado-Codina
Sep 16, 2020·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Daniel G Fuller, Yueren Wang
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Aug 18, 2017·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Nicole CarntFiona Stapleton
Dec 9, 2020·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·Chandra V MicklesKathryn Richdale
Dec 12, 2020·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·Gauri Shankar ShresthaNicole Carnt
May 23, 2020·Eye & Contact Lens·David Mingo-BotínFrancisco José Muñoz-Negrete
Apr 13, 2020·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·Nathan EfronMark D Willcox
Mar 9, 2021·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·Alan YeeLyndon Jones
Mar 11, 2021·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Lily HoAlex Hui
Dec 8, 2020·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·G Lynn MitchellBernard Rosner
Mar 30, 2021·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·Fiona StapletonJames S Wolffsohn
Mar 30, 2021·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·James S WolffsohnFiona Stapleton
Sep 28, 2021·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Memoona ArshadFiona Stapleton

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