Feb 7, 2017

Case-control study of cumulative cigarette tar exposure and lung and upper aerodigestive tract cancers

International Journal of Cancer. Journal International Du Cancer
Travis J MeyersZuo-Feng Zhang

Abstract

The development of comprehensive measures for tobacco exposure is crucial to specify effects on disease and inform public health policy. In this population-based case-control study, we evaluated the associations between cumulative lifetime cigarette tar exposure and cancers of the lung and upper aerodigestive tract (UADT). The study included 611 incident cases of lung cancer; 601 cases of UADT cancers (oropharyngeal, laryngeal and esophageal cancers); and 1,040 cancer-free controls. We estimated lifetime exposure to cigarette tar based on tar concentrations abstracted from government cigarette records and self-reported smoking histories derived from a standardized questionnaire. We analyzed the associations for cumulative tar exposure with lung and UADT cancer, overall and according to histological subtype. Cumulative tar exposure was highly correlated with pack-years among ever smoking controls (Pearson coefficient = 0.90). The adjusted odds ratio (95% confidence limits) for the estimated effect of about 1 kg increase in tar exposure (approximately the interquartile range in all controls) was 1.61 (1.50, 1.73) for lung cancer and 1.21 (1.13, 1.29) for UADT cancers. In general, tar exposure was more highly associated with small...Continue Reading

  • References30
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References

  • References30
  • Citations1

Citations

Mentioned in this Paper

Study
Tobacco
Lung
Public Policy on Health
Neoplasms
Nicotiana
Small Cell Carcinoma of Lung
Small Lymphocyte
Non-Small Cell Lung Carcinoma
Carcinoma of Lung

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