Case control study of risk factors and ophthalmological outcomes of very low birth weight infants with Type 1 retinopathy of prematurity.

Singapore Medical Journal
Tryphena Rachel NgLe Ye Lee

Abstract

We evaluated the risk factors associated with Type 1 retinopathy of prematurity (ROP) in very low birth weight (VLBW) infants and compared ophthalmologic outcomes between cases with Type 1 ROP who received treatment and gestational age-matched controls with mild or no ROP not requiring treatment. This was a retrospective case-control study of VLBW infants born in National University Hospital, Singapore, from January 2001 to December 2013. 17 cases with Type 1 ROP were each matched for gestational age with controls who had either mild (below Stage 2) or no ROP. Antenatal, perinatal and postnatal variables, as well as childhood ophthalmologic outcomes, were collected from their clinical records and analysed. The number of packed cell transfusions and highest fraction of inspired oxygen given at weeks 7-10 were found to be statistically significant on multivariate analysis (p = 0.045 and p = 0.049, respectively). None of the infants had blindness or retinal detachment, and there were no significant differences in refractive errors between the groups at 1-4 years of age. Strabismus at four years of age was more common in the group with Type 1 ROP (p = 0.023). Increased episodes of blood transfusions and chronic lung disease requiri...Continue Reading

References

Oct 1, 1993·European Journal of Pediatrics·R W CookeA M Weindling
Feb 1, 1997·European Journal of Pediatrics·L JamesS Naik
Apr 29, 1998·Pediatrics·M MittalR D Higgins
Mar 14, 2001·Early Human Development·C DaniF F Rubaltelli
Aug 14, 2001·Archives of Ophthalmology·UNKNOWN Cryotherapy for Retinopathy of Prematurity Cooperative Group
Sep 5, 2001·Journal of Perinatology : Official Journal of the California Perinatal Association·M F Haroon Parupia, R Dhanireddy
May 17, 2002·Seminars in Neonatology : SN·J R Mccolm, B W Fleck
Sep 5, 2003·The New England Journal of Medicine·Lisa Maree AskieJudy Margaret Simpson
May 12, 2004·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Lois E H Smith
Jul 13, 2005·Archives of Ophthalmology·UNKNOWN International Committee for the Classification of Retinopathy of Prematurity
May 23, 2006·The British Journal of Ophthalmology·E McLooneB Lanigan
Oct 31, 2006·Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus·Imren AkkoyunYonca A Akova
Mar 6, 2007·Archives of Disease in Childhood. Fetal and Neonatal Edition·W Tin, S Gupta
Nov 21, 2007·The British Journal of Ophthalmology·Gerd HolmströmKeryn A Williams
Oct 7, 2008·Eye·A R WilkinsonUNKNOWN British Association of Perinatal Medicine
Sep 10, 2011·Seminars in Fetal & Neonatal Medicine·Jennifer Lee, Olaf Dammann
Dec 14, 2011·Archives of Ophthalmology·Kristi Washburn TolsmaOlaf Dammann
Jun 21, 2013·Lancet·Ann HellströmOlaf Dammann
Mar 11, 2015·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Lu RuanXin Huang
Oct 21, 2015·Journal of Neonatal-perinatal Medicine·K ThomasK E Dow
Nov 14, 2015·Journal of Korean Medical Science·Jong Hee HwangEllen Ai-Rhan Kim
Jun 7, 2018·JAMA : the Journal of the American Medical Association·Lisa M AskieUNKNOWN Neonatal Oxygenation Prospective Meta-analysis (NeOProM) Collaboration

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