PMID: 8972255Oct 1, 1996Paper

Case-control study of risk factors for cervical squamous cell neoplasia in Denmark. IV: role of smoking habits

European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)
S K KjaerJ E Bock

Abstract

The role of smoking and other risk factors for cervical neoplasia was investigated in a population-based case-control study of 586 women with histologically verified cervical squamous-cell carcinoma in situ (CIS), and 59 women with invasive squamous-cell cervical cancer from Copenhagen. Controls were randomly selected from the general female population using the computerized Danish Central Population Register. After adjustment for a variety of confounding variables, which were all significantly associated with CIS risk and included age, number of partners, proportion of sexually active life without barrier contraceptive use, years with intra-uterine devices, number of births, and age at first episode of genital warts (as a proxy measure for human papillomavirus exposure), current cigarette smoking was found to be significantly associated with CIS [adjusted relative risk (RR) = 2.4; 95% confidence interval (CI): 1.7-3.4]. Ex-smokers had a lower, but still significantly increased risk (RR = 1.6; 95% CI: 1.0-2.7). A dose-response relationship was present, especially for number of cigarettes smoked per day. In contrast, the crude estimates showed a weak association between invasive cervical cancer and smoking, which however disappe...Continue Reading

Citations

Jul 10, 2002·Cancer Detection and Prevention·Ann L CokerLucia Pirisi
Jul 12, 2003·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Harry W HaverkosWallace Pickworth
Jun 3, 2008·Clinical Oncology : a Journal of the Royal College of Radiologists·E J Maher, A Denton
Jul 14, 2007·Preventive Medicine·Henry C BarryLinda French
Oct 6, 2005·International Journal of Cancer. Journal International Du Cancer·UNKNOWN International Collaboration of Epidemiological Studies of Cervical CancerS Sweetland
May 7, 2011·American Journal of Otolaryngology·Parul SinhaWilliam M Mendenhall
Jan 29, 2003·Environmental and Molecular Mutagenesis·Carlos H Sierra-TorresStephen K Tyring
Aug 7, 1998·APMIS. Supplementum·S K Kjaer
Mar 29, 2011·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Angiolo GadducciAndrea Riccardo Genazzani
Apr 21, 1999·International Journal of Cancer. Journal International Du Cancer·N YlitaloH O Adami

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